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Titolo:
EFFECT OF ADENOSINE ON HEART-RATE IN ISOLATED MUSKRAT AND GUINEA-PIG HEARTS
Autore:
MCKEAN TA; STERLING H; STREEBY DR; LYNCH AE; LACROIX C; VESTAL RE;
Indirizzi:
UNIV IDAHO,DEPT BIOL SCI MOSCOW ID 83843 DEPT VET AFFAIRS MED CTR BOISE ID 83702 UNIV WASHINGTON,SCH MED,DEPT PHYSIOL & BIOPHYS SEATTLE WA 98195
Titolo Testata:
The American journal of physiology
fascicolo: 1, volume: 265, anno: 1993,
parte:, 2
pagine: 80000307 - 80000315
SICI:
0002-9513(1993)265:1<80000307:EOAOHI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIOVENTRICULAR-CONDUCTION; INTERSTITIAL ADENOSINE; NUCLEOSIDE TRANSPORT; WEDDELL SEALS; BINDING; 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE; METABOLISM; RECEPTORS; HYPOXIA; GLUCOSE;
Keywords:
HYPOXIA; PHENYLISOPROPYL ADENOSINE; NUCLEOSIDE TRANSPORTER; RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
T.A. Mckean et al., "EFFECT OF ADENOSINE ON HEART-RATE IN ISOLATED MUSKRAT AND GUINEA-PIG HEARTS", The American journal of physiology, 265(1), 1993, pp. 80000307-80000315

Abstract

The purpose of this study was to co pare the responses of isolated hearts of the diving muskrat wit the nondiving guinea pig (GP) to determine the contribution adenosine (ADO) to the profound bradycardia that was seen in isolated muskrat hearts during exposure to hypoxia. Muskrat hearts were more sensitive than GP hearts to the heart rate-loweringeffects of exogenously applied ADO or a stable AD analogue, (R)-N6-(phenylisopropyl)adenosine. The hearts both species were unpaced, and the bradycardia appeared to b due to high degree of atrioventricular block. Radioligand binding with 8-cyclopentyl-1,3-[H-3]dipropylxanthine to A1-ADO receptors was greater in cardiac membranes prepared from G hearts than from muskrat hearts. Nucleoside transporter antagonist binding was also greater in GP hearts compared with muskrats. This was determined by membrane binding of [H-3]-nitrobenzylthioinosine, an antagonist of nucleoside transport. Both muskrat and GP hearts responded to 30 min of hypoxic perfusion by releasing ADO into the coronary effluent; however the muskrat hearts released approximately five times more than the GP hearts. When hearts were subjected to hypoxia in the presence of ADO deaminase, theophylline, or 8-(p-sulfophenyl)theophylline, the hypoxia-induced bradycardia was blocked in the GP hearts and either slightly reduced or no affected in muskrat hearts. In contrast to GP hearts, muskrat hearts release larger amounts of ADO during hypoxia andare more sensitive to the negative chronotropic effects of exogenously administered ADO; yet the hypoxia-induced bradycardia does not appear to be exclusively mediated by ADO in the muskrat as it is in the isolated GP heart.

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Documento generato il 07/07/20 alle ore 13:44:45