Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
RELATIONSHIP OF NEUROPATHY TARGET ESTERASE INHIBITION TO NEUROPATHOLOGY AND ATAXIA IN HENS GIVEN ORGANOPHOSPHORUS ESTERS
Autore:
EHRICH M; JORTNER BS; PADILLA S;
Indirizzi:
VIRGINIA MARYLAND REG COLL VET MED BLACKSBURG VA 24061 US EPA RES TRIANGLE PK NC 27711
Titolo Testata:
Chemico-biological interactions
fascicolo: 1-3, volume: 87, anno: 1993,
pagine: 431 - 437
SICI:
0009-2797(1993)87:1-3<431:RONTEI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED DELAYED NEUROTOXICITY; ORTHO-CRESYL PHOSPHATE;
Keywords:
NEUROPATHY TARGET ESTERASE; HEN; ORGANOPHOSPHORUS-INDUCED DELAYED NEUROPATHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
M. Ehrich et al., "RELATIONSHIP OF NEUROPATHY TARGET ESTERASE INHIBITION TO NEUROPATHOLOGY AND ATAXIA IN HENS GIVEN ORGANOPHOSPHORUS ESTERS", Chemico-biological interactions, 87(1-3), 1993, pp. 431-437

Abstract

Adult White Leghorn hens were acutely exposed to 3 dosages of the following organophosphorus compounds: mipafox, tri-ortho-tolyl phosphate (TOTP), phenyl saligenin phosphate, and diisopropylphosphorofluoridate(DFP). Neuropathy target esterase (NTE) activity was measured in brain and spinal cord 4 or 48 h after exposure. Ataxia was assessed using an 8-point rating scale on days 9 through 21 after administration, andneuropathological examination was conducted on samples collected fromperfusion-fixed animals on day 21. Morphological alterations were indicated by lesion scores between 0 (no lesions) and 4 (diffuse involvement of spinal cord tracts and > 25% degeneration of peripheral nerve fibers). Dosages of mipafox (30 mg/kg i.p.), TOTP (500 mg/kg p.o.), phenyl saligenin phosphate (2.5 mg/kg i.m.) and DFP (1 mg/kg s.c.) that were capable of inhibiting NTE > 80% in both brain and spinal cord preceded ataxia which reached maximal levels (scores of 7 - 8), and development of lesions scored as 4. Hens were notably impaired (ataxia scores of 3 - 4) 21 days after administration of dosages of mipafox (3 and 6 mg/kg), TOTP (90 mg/kg), phenyl saligenin phosphate (0.1 and 0.2 mg/kg), and DFP (0.4 mg/kg) when spinal cord NTE was inhibited 40 - 75%. Lesions were, however, only noted in spinal cord and peripheral nervesof hens given TOTP or DFP (scores 1 - 3). These data indicate that inhibition of spinal cord NTE > 80% was predictive of severe ataxia and extensive pathology in the hen and that less NTE inhibition was indicative of less severe ataxia and a lower score for neuropathological damage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 10:11:26