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Titolo:
INTERLEUKIN-7 ENHANCES COLONY GROWTH AND INDUCES CD20 ANTIGEN OF A PH-LEUKEMIA CELL-LINE, OM9-22( ACUTE LYMPHOBLASTIC)
Autore:
OHYASHIKI K; MIYAUCHI J; OHYASHIKI JH; SAITO M; YAGUCHI M; INATOMI Y; NAKAZAWA S; WADA H; MIZUTANI S; MATSUO Y; MINOWADA J; TOYAMA K;
Indirizzi:
TOKYO MED COLL,DEPT INTERNAL MED 1,6-7-1 NISHISHINJUKU,SHINJUKU KU TOKYO 160 JAPAN NATL CHILDRENS HOSP,CENT LABS,DIV PATHOL TOKYO 154 JAPAN NATL CHILDRENS MED RES CTR,DIV VIROL TOKYO JAPAN KEIO UNIV,SCH MED,DEPT PEDIAT TOKYO 108 JAPAN FUJISAKI CELL CTR OKAYAMA JAPAN YAMANASKI MED COLL,DEPT PEDIAT YAMANASHI JAPAN
Titolo Testata:
Leukemia
fascicolo: 7, volume: 7, anno: 1993,
pagine: 1034 - 1040
SICI:
0887-6924(1993)7:7<1034:IECGAI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATES TYROSINE PHOSPHORYLATION; PHILADELPHIA-CHROMOSOME; B-CELLS; CLONAL PROLIFERATION; REGION GENES; RECEPTOR; DIFFERENTIATION; IMMUNOGLOBULIN; INVITRO; IL-7;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
K. Ohyashiki et al., "INTERLEUKIN-7 ENHANCES COLONY GROWTH AND INDUCES CD20 ANTIGEN OF A PH-LEUKEMIA CELL-LINE, OM9-22( ACUTE LYMPHOBLASTIC)", Leukemia, 7(7), 1993, pp. 1034-1040

Abstract

A newly established human leukemia cell line, OM9;22, is reported, with B-precursor immunophenotype (CD10+ CD19+ CD22+ HLA- DR+ Cmu-) and CD13 antigen, originated from a 19-year-old female patient with Philadelphia (Ph) chromosome-positive acute lymphoblastic leukemia (ALL). TheOM9;22 cells carry a Philadelphia (Ph) translocation and hybrid message detected by a minor-breakpoint cluster region (BCR) exon 1/ABL exon2 junctional probe using reverse transcriptase polymerase chain reaction. The genetic alterations are consistent with those observed in thedonor's leukemia cells, allowing us to conclude that this cell line is a minor-BCR rearranged Ph-positive ALL (Ph + ALL). Colony formation of the OM9;22 cells in methylcellulose culture is enhanced by the addition of human interleukin 7 (IL-7). in liquid culture, more than 80% of IL-7-treated OM9;22 cells express CD20 antigen but fail to express surface immunoglobulins or cytoplasmic mu-chain, indicating that the cells have a potential of limited maturation by IL-7. By contrast, IL-4 suppresses the colony formation of the OM9;22 cells. These findings suggest that this cell line might be a model of B-precursor human leukemia with proliferative capability by IL-7.

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Documento generato il 27/11/20 alle ore 15:16:58