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Titolo:
PRIMARY STRUCTURE OF THE HUMAN MUSCLE ACETYLCHOLINE-RECEPTOR - CDNA CLONING OF THE GAMMA-SUBUNIT AND EPSILON-SUBUNIT
Autore:
BEESON D; BRYDSON M; BETTY M; JEREMIAH S; POVEY S; VINCENT A; NEWSOMDAVIS J;
Indirizzi:
JOHN RADCLIFFE HOSP,INST MOLEC MED,NEUROSCI GRP OXFORD OX3 9DU ENGLAND UNIV LONDON UNIV COLL,GALTON LAB,MRC,HUMAN BIOCHEM GENET UNIT LONDON WC1E 6BT ENGLAND
Titolo Testata:
European journal of biochemistry
fascicolo: 2, volume: 215, anno: 1993,
pagine: 229 - 238
SICI:
0014-2956(1993)215:2<229:PSOTHM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-LINE TE671; ALPHA-SUBUNIT; BETA-SUBUNIT; DELTA-SUBUNIT; CALF-MUSCLE; 2 ISOFORMS; RAT MUSCLE; GENE; SEQUENCE; CHROMOSOME-17;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
D. Beeson et al., "PRIMARY STRUCTURE OF THE HUMAN MUSCLE ACETYLCHOLINE-RECEPTOR - CDNA CLONING OF THE GAMMA-SUBUNIT AND EPSILON-SUBUNIT", European journal of biochemistry, 215(2), 1993, pp. 229-238

Abstract

cDNA sequences encompassing the full coding region for the human muscle acetylcholine receptor (AChR) epsilon and gamma subunits have been isolated. The deduced amino-acid sequences indicate that the mature epsilon subunit contains 473 amino acids and is preceded by a 20-amino-acid signal peptide. As predicted from genomic clones, the gamma subunit contains 495 amino acids preceded by a 22-amino-acid signal peptide. In common with the human alpha, beta, gamma and delta subunits the epsilon subunit is highly conserved between mammalian species. The epsilon subunit gene is not closely linked to the gamma and delta subunits on chromosome 2 but rather is located with the beta subunit on chromosome 17. Expression of the alpha-, beta-, gamma-, delta- and epsilon-subunit cRNAs in rabbit-reticulocyte lysates followed by analysis on SDS/PAGE show glycosylated proteins with apparent molecular masses of 44-60 kDa.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 04:48:54