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Titolo:
REVERSAL OF DIASTOLIC DYSFUNCTION IN BORDERLINE HYPERTENSION BY LONG-TERM MEDICAL-TREATMENT - LONGITUDINAL EVALUATION BY PULSED DOPPLER-ECHOCARDIOGRAPHY
Autore:
KAPUKU GK; SETO S; MORI H; MORI M; UTSUNOMIA T; SUZUKI S; OKU Y; YANO K;
Indirizzi:
NAGASAKI UNIV,SCH MED,DEPT INTERNAL MED 3,7-1 SAKAMOTO MACHI NAGASAKI852 JAPAN
Titolo Testata:
American journal of hypertension
fascicolo: 7, volume: 6, anno: 1993,
parte:, 1
pagine: 547 - 553
SICI:
0895-7061(1993)6:7<547:RODDIB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Keywords:
BORDERLINE HYPERTENSION; PULSED DOPPLER ECHOCARDIOGRAPHY; DIASTOLIC FUNCTION; ANGIOTENSIN CONVERTING ENZYME INHIBITOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
G.K. Kapuku et al., "REVERSAL OF DIASTOLIC DYSFUNCTION IN BORDERLINE HYPERTENSION BY LONG-TERM MEDICAL-TREATMENT - LONGITUDINAL EVALUATION BY PULSED DOPPLER-ECHOCARDIOGRAPHY", American journal of hypertension, 6(7), 1993, pp. 547-553

Abstract

This study aimed to assess the left ventricular diastolic function ofborderline hypertensive patients (BHT) and to determine the effect oflong-term blood pressure control by an angiotensin converting enzyme inhibitor on the left ventricular filling profile. Pulsed Doppler echocardiograms were obtained from 18 BHT (14 men, 4 women; mean age: 55 years) and 20 age-sex matched normotensive controls. Studies were done at rest and immediately after exercise on a supine ergometer bicycle. Of the 18 patients, 11 were treated with delapril (30 mg/day) and followed up with longitudinal studies for 24 weeks. At baseline, BHT had anormal left ventricular structure. They showed a decreased peak velocity of early filling (E) (43 +/- 7 v 56 +/- 13 cm/sec, P < .01) and E/A ratio (0.83 +/- 0.2 v 1.08 +/- 0.3, P < .01), whereas peak velocity of late filling (A) and deceleration time (Dec T) were similar in the two groups. Exercise-enhanced filling indices were observed in both groups. Following blood pressure control, no change was observed in the left ventricular morphology. In contrast, progressive improvement of resting and after exercise peak velocity of early filling and E/A ratiowere achieved. This indicates that long-term angiotensin converting enzyme inhibition ameliorates cardiac function in borderline hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 04:13:30