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Titolo:
SUPERSENSITIVITY TO THE STIMULANT ACTION OF NORADRENALINE ON HUMAN MYOMETRIUM NEAR-TERM
Autore:
PENNEFATHER JN; PAULL JD; STORY ME; ZICCONE SP;
Indirizzi:
MONASH UNIV,DEPT PHARMACOL CLAYTON VIC 3168 AUSTRALIA ROYAL WOMENS HOSP,DEPT CARDIOTHORAC SURG CARLTON VIC 3053 AUSTRALIA
Titolo Testata:
Reproduction, fertility and development
fascicolo: 1, volume: 5, anno: 1993,
pagine: 39 - 48
SICI:
1031-3613(1993)5:1<39:STTSAO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG MYOMETRIUM; ADRENERGIC-RECEPTOR; UTERINE ACTIVITY; AMNIOTIC-FLUID; GAP-JUNCTIONS; HUMAN-UTERUS; PREGNANCY; CATECHOLAMINES; CONTRACTILITY; BINDING;
Keywords:
ALPHA-ADRENOCEPTORS; CESAREAN SECTION; HYSTERECTOMY; NORADRENALINE; PREGNANCY; SUPERSENSITIVITY; TYRAMINE; UTERINE CONTRACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
J.N. Pennefather et al., "SUPERSENSITIVITY TO THE STIMULANT ACTION OF NORADRENALINE ON HUMAN MYOMETRIUM NEAR-TERM", Reproduction, fertility and development, 5(1), 1993, pp. 39-48

Abstract

Noradrenaline (10-50 nm) and tyramine (0-05-1 mm) enhanced contractile force elicited by field stimulation of strips of myometrium from non-pregnant and pregnant women. In higher concentrations, noradrenaline produced sustained contractions. The EC50 Values for noradrenaline were 0.4 mum in tissues from pregnant women and 3.1 mum in tissues fron non-pregnant women; maximum responses were greater in the former tissues. In addition, the effects of noradrenaline on myometrium from pregnant women were more marked on the inner layer than on the outer layer, antagonized by the alpha1-adrenoceptor antagonist prazosin (0.1 and 1.0 mum), and unaffected by the inhibitor of neuronal uptake, nisoxetine(0.1 mum). Taken together, these observations confirm that supersensitivity to noradrenaline develops during pregnancy and is present near term. The supersensitivity to noradrenaline at term can be attributed only in part to a decrease in its removal by the sympathetic innervation, which declines towards term, because responses to tyramine were also enhanced in tissues from pregnant women. It is possible that gap junction formation may also contribute to this supersensitivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:06:22