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Titolo:
EFFECTS OF ENDOGENOUS AND EXOGENOUS N-3 AND N-6 FATTY-ACIDS ON MICROSOMAL SYNTHESIS OF DOCOSAHEXAENOIC ACID IN-VITRO
Autore:
KANAZAWA A; FUJIMOTO K;
Indirizzi:
TOHOKU UNIV,FAC AGR,DEPT APPL BIOCHEM,AOBA KU SENDAI 981 JAPAN
Titolo Testata:
Journal of nutritional science and vitaminology
fascicolo: 3, volume: 39, anno: 1993,
pagine: 253 - 262
SICI:
0301-4800(1993)39:3<253:EOEAEN>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-LINOLENIC ACID; RAT-LIVER MICROSOMES; EICOSAPENTAENOIC ACID; CHAIN ELONGATION; DESATURATION; CELLS; RETROCONVERSION; CHOLESTEROL; BRAIN;
Keywords:
ARACHIDONIC ACID; DHA; EPA; N-3/N-6 RATIO; MICROSOME; LIVER; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
A. Kanazawa e K. Fujimoto, "EFFECTS OF ENDOGENOUS AND EXOGENOUS N-3 AND N-6 FATTY-ACIDS ON MICROSOMAL SYNTHESIS OF DOCOSAHEXAENOIC ACID IN-VITRO", Journal of nutritional science and vitaminology, 39(3), 1993, pp. 253-262

Abstract

Effects of endogenous and exogenous polyunsaturated fatty acids (PUFA) on microsomal synthesis of docosahexaenoic acid (DHA) from eicosapentaenoic acid (EPA) in vitro were studied using rat livers. Liver microsomes prepared from three groups of rats which had been fed n-3/n-6 ratios of 0.01, 0.39, and 2.70, respectively, for 1 month, were incubated with [1-C-14]EPA at 37-degrees-C for 30 min. There were no significant differences between the formations of docosapentaenoic acid (DPA) or DHA in the groups. Liver microsomes from rats fed a diet with an n-3/n-6 ratio of 2.70 for 3 weeks were then incubated with [1-C-14] EPA in the presence of unlabeled DHA or arachidonic acid (AA). The additional DHA did not have any effect. However, a significant inhibition of DHA synthesis was observed by addition of AA (EPA/AA=5:2). These results suggest that the microsomal biosynthesis of DHA in rat liver is not susceptible to feedback inhibition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 10:25:15