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Titolo:
EFFECT OF BILATERAL-NEPHRECTOMY ON HYPERTENSION PRODUCED BY ACUTE AORTIC COARCTATION
Autore:
FAZAN R; MACHADO BH; SALGADO MCO; SALGADO HC;
Indirizzi:
UNIV SAO PAULO,FAC MED RIBEIRAO PRETO,DEPT FISIOL BR-14049 RIBEIRAO PRE SP BRAZIL UNIV SAO PAULO,FAC MED RIBEIRAO PRETO,DEPT FISIOL BR-14049 RIBEIRAO PRE SP BRAZIL UNIV SAO PAULO,FAC MED RIBEIRAO PRETO,DEPT FARMACOL BR-14049 RIBEIRAOPRE SP BRAZIL
Titolo Testata:
Brazilian journal of medical and biological research
fascicolo: 7, volume: 26, anno: 1993,
pagine: 765 - 771
SICI:
0100-879X(1993)26:7<765:EOBOHP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONSCIOUS RAT; RENAL NERVES; BLOOD-FLOW; ANGIOTENSIN; AFFERENT; VASOPRESSIN;
Keywords:
HYPERTENSION; HEMODYNAMICS OF AORTIC COARCTATION; AORTIC RESISTANCE; AORTIC FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
R. Fazan et al., "EFFECT OF BILATERAL-NEPHRECTOMY ON HYPERTENSION PRODUCED BY ACUTE AORTIC COARCTATION", Brazilian journal of medical and biological research, 26(7), 1993, pp. 765-771

Abstract

1. The hemodynamic responses to acute (45 min) aortic coarctation were studied in conscious intact (N=7) or bilaterally nephrectomized (N=7) Wistar rats (250-320 g). The degree of constriction of the aorta wasmonitored by reducing aortic flow (measured with a pulsed Doppler flowmeter) to 40% of the basal level. 2. The nephrectomized rats presented a smaller (P<0.05) increase in carotid pressure (14-17%) than the intact rats (25-36%). Although the aortic constriction reduced significantly the aortic flow to 40% of the basal level in both groups of rats,the calculated change in aortic resistance imposed by coarctation in the intact group was significantly (P<0.05) higher (167-292%) than that observed (173-183%) in the nephrectomized group, except 5 min after coarctation. 3. The hemodynamic data obtained in the present study confirm our findings that nephrectomized rats display a blunted hypertensive response to acute aortic coarctation which is attributed mainly tothe mechanical effect of constriction. In addition, the present data indicate that the release of vasopressor substances triggered by the kidneys in intact subjects are responsible for the gradual increase in aortic resistance during coarctation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:28:44