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Titolo:
MAGNESIUM-SULFATE INHIBITS OXYTOCIN-INDUCED CALCIUM MOBILIZATION IN HUMAN PUERPERAL MYOMETRIAL CELLS - POSSIBLE INVOLVEMENT OF INTRACELLULAR FREE MAGNESIUM CONCENTRATION
Autore:
MIZUKI J; TASAKA K; MASUMOTO N; KASAHARA K; MIYAKE A; TANIZAWA O;
Indirizzi:
OSAKA UNIV,SCH MED,DEPT OBSTET & GYNECOL,2-2 YAMADAOKA SUITA OSAKA 565 JAPAN OSAKA UNIV,SCH MED,DEPT OBSTET & GYNECOL,2-2 YAMADAOKA SUITA OSAKA 565 JAPAN
Titolo Testata:
American journal of obstetrics and gynecology
fascicolo: 1, volume: 169, anno: 1993,
pagine: 134 - 139
SICI:
0002-9378(1993)169:1<134:MIOCMI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; PREGNANT RAT UTERUS; CARDIAC MYOCYTES; CONTRACTION; SUPEROXIDE; NIFEDIPINE;
Keywords:
UTERINE CONTRACTION; MAGNESIUM SULFATE; OXYTOCIN; INTRACELLULAR FREE CALCIUM CONCENTRATION; INTRACELLULAR FREE MAGNESIUM CONCENTRATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
J. Mizuki et al., "MAGNESIUM-SULFATE INHIBITS OXYTOCIN-INDUCED CALCIUM MOBILIZATION IN HUMAN PUERPERAL MYOMETRIAL CELLS - POSSIBLE INVOLVEMENT OF INTRACELLULAR FREE MAGNESIUM CONCENTRATION", American journal of obstetrics and gynecology, 169(1), 1993, pp. 134-139

Abstract

OBJECTIVE: Our purpose was to elucidate the mechanisms of the tocolytic action of Mg2+ on the human myometrium. STUDY DESIGN: The effects of extracellular Mg2+ on oxytocin-induced increases in the intracellular free Ca2+ concentration in human puerperal myometrial cells were examined by means of indo-1-AM. The changes in the intracellular free Mg2 concentration under various conditions were also measured with Mg2+-fura-2-AM. RESULTS: The increase in intracellular free Ca2+ concentration induced by oxytocin was reduced to 26% of that in the normal solution 20 minutes after replacement of the normal solution with an extracellular Mg2+ Solution, 10 mmol/L. When extracellular Ca2+ was removed,the increase in intracellular free Ca2+ concentration was not suppressed even 20 minutes after the replacement. A solution of extracellularMg2+ concentration, 10 mmol/L, raised the intracellular free Mg2+ concentration gradually, by approximately 150% in 20 minutes, concomitantwith the suppression of the response to oxytocin in the intracellularfree Ca2+ concentration. CONCLUSION: High intracellular free Mg2+ concentration, caused by high extracellular Mg2+, is essential for suppression of oxytocin-induced Ca2+ influx across the cell membrane; this presumably results in inhibition of uterine contractions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 21:56:34