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Titolo:
TUBULAR PROTEINURIA IN STEROID SENSITIVE MULTI-RELAPSING NEPHROTIC SYNDROME
Autore:
PIQUERAS AI; SHAH V; HULTON SA; BARRATT TM; DILLON MJ;
Indirizzi:
INST CHILD HLTH,MED UNIT,30 GUILFORD ST LONDON WC1N 1EH ENGLAND INST CHILD HLTH,MED UNIT,30 GUILFORD ST LONDON WC1N 1EH ENGLAND
Titolo Testata:
Clinical nephrology
fascicolo: 1, volume: 40, anno: 1993,
pagine: 26 - 30
SICI:
0301-0430(1993)40:1<26:TPISSM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYL-BETA-GLUCOSAMINIDASE; RETINOL-BINDING-PROTEIN; MOLECULAR-WEIGHT PROTEINS; RENAL-DISEASE; URINARY-EXCRETION; BETA-2-MICROGLOBULIN; MICROALBUMINURIA; FILTRATION; CHILDREN; ALBUMIN;
Keywords:
TUBULAR PROTEINURIA; N-ACETYL-BETA-D-GLUCOSAMINIDASE; RETINOL BINDING PROTEIN; NEPHROTIC SYNDROME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
A.I. Piqueras et al., "TUBULAR PROTEINURIA IN STEROID SENSITIVE MULTI-RELAPSING NEPHROTIC SYNDROME", Clinical nephrology, 40(1), 1993, pp. 26-30

Abstract

The urinary excretion of N-acetyl-beta-D-glucosaminidase (UNAG) and retinol binding protein (URBP) was studied in 65 children with steroid sensitive multirelapsing nephrotic syndrome (MRNS): 28 on cyclosporin A (CyA) therapy, 22 on prednisolone (P), 15 off-treatment and in 32 normal children to assess renal tubular damage or dysfunction. The urinary protein excretion was expressed in relation to that of creatinine (UNAG/UC in mumol pnp/h/mmol; URBP/UC in mug/mmol). There was a weak but significantly negative correlation between age and both, UNAG/UC (r = -0.38, p<0.01) and URBP/UC (r = -0.50, p<0.05) in normal children, but not in nephrotics. In normals and in patients off steroids an association between these two proteins was found (r = 0.38, p<0.05; r = 0.56, p<0.05 respectively). Geometric mean UNAG/UC was significantly higher in nephrotics on CyA therapy (26.5 +/- 4.0), and on P (37.0 +/- 7.9) as well as in those off-treatment (16.3 +/- 3.1) compared to normal children (9.3 +/- 3.4). There was a further increase in those with raised urinary albumin: creatinine ratio (UA/UC) (>0.1 mg/mg). URBP/UC was not increased in any of the groups of children with MRNS. Raised NAGin urine may therefore indicate active nephrotic syndrome rather thanbeing due to the drug therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 05:17:23