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Titolo:
INCREASED EXPRESSION OF THE LACTATE DEHYDROGENASE-M SUBUNIT IN MYOCARDIAL REGIONS WITH DECREASED THALLIUM UPTAKE
Autore:
LIN L; KAIJSER L; LISKA J; SYLVEN C; HOLMGREN A; LINDSTROM K; JANSSON E;
Indirizzi:
HUDDINGE HOSP,DEPT CLIN PHYSIOL S-14186 HUDDINGE SWEDEN HUDDINGE HOSP,DEPT CLIN PHYSIOL S-14186 HUDDINGE SWEDEN KAROLINSKA HOSP,THORAC CLIN,DEPT CLIN PHYSIOL S-10401 STOCKHOLM 60 SWEDEN KAROLINSKA HOSP,DEPT THORAC SURG S-10401 STOCKHOLM 60 SWEDEN HUDDINGE HOSP,KAROLINSKA INST,DEPT INTERNAL MED S-14186 HUDDINGE SWEDEN
Titolo Testata:
Cardiovascular Research
fascicolo: 7, volume: 27, anno: 1993,
pagine: 1300 - 1305
SICI:
0008-6363(1993)27:7<1300:IEOTLD>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORMAL HUMAN-HEART; PERIPHERAL ARTERIAL INSUFFICIENCY; CALF MUSCLE ADAPTATION; HUMAN SKELETAL-MUSCLE; DIFFERENT PARTS; INTERMITTENT CLAUDICATION; ISOENZYME ACTIVITIES; CARDIAC HYPERTROPHY; ENERGY-METABOLISM; KEY ENZYMES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
L. Lin et al., "INCREASED EXPRESSION OF THE LACTATE DEHYDROGENASE-M SUBUNIT IN MYOCARDIAL REGIONS WITH DECREASED THALLIUM UPTAKE", Cardiovascular Research, 27(7), 1993, pp. 1300-1305

Abstract

Objective: In ischaemic heart disease, the heart muscle is subjected to repeated episodes of regional ischaemia or to a constant underperfusion. The purpose of the present investigation was to study the myocardial metabolic adaptation to this stress. Methods: Eighteen male patients with ischaemic heart disease were studied by biopsies taken from the left ventricular septum during bypass surgery. Citrate synthase, total lactate dehydrogenase and its H and M subunits, coenzyme Q10, and myoglobin were determined in all biopsies. Concentrations of ATP, ADP,and AMP were determined and energy charge calculated in the biopsies from the patients with ischaemic heart disease. Biopsies from the septal region of hearts obtained from brain dead kidney and liver donors were used as reference and preoperative myocardial thallium scintigraphy was performed in the patients with ischaemic heart disease to relatethe myocardial biochemical markers to thallium uptake at the biopsy site. Results: Myocardial activities of citrate synthase as well as contents of coenzyme Q10 and myoglobin in patients with ischaemic heart disease were not different from those of the reference group, and no linear relation was found between these three markers on the one hand and thallium uptake on the other. The energy charge was directly relatedand the M subunit of lactate dehydrogenase inversely related to the thallium uptake. Conclusion: The results suggest an absence of adaptation to ischaemia in terms of increased myocardial oxidative capacity and O2 transport and storage capacity. Furthermore, it is indicated thata stressed energy metabolism with increasing severity of ischaemic heart disease enhances anaerobic metabolism and induces a shift in myocardial lactate dehydrogenase subunit fractions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:37:22