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Titolo:
HEPARIN DOES NOT INHIBIT ONCOGENE INDUCTION IN RABBIT AORTA FOLLOWINGBALLOON DENUDATION
Autore:
HAMON M; BAUTERS C; WERNERT N; COURTIN P; DELCAYRE C; ADAMANTIDIS M; LABLANCHE JM; BERTRAND ME; DUPUIS B; SWYNGHEDAUW B;
Indirizzi:
HOP CARDIOL,SERV CARDIOL B & HEMODYNAM,BLVD PROFESSEUR J LECLERCQ F-59037 LILLE FRANCE INSERM,U127 F-75005 PARIS FRANCE UNIV LILLE,DEPT PHARMACOL LILLE FRANCE UNIV LILLE,DEPT CARDIOL LILLE FRANCE UNIV LILLE,DEPT PATHOL LILLE FRANCE
Titolo Testata:
Cardiovascular Research
fascicolo: 7, volume: 27, anno: 1993,
pagine: 1209 - 1213
SICI:
0008-6363(1993)27:7<1209:HDNIOI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; MYC MESSENGER-RNA; ADULT-RAT HEART; C-MYC; CORONARY ANGIOPLASTY; CELLULAR PROLIFERATION; ARTERIAL INJURY; PROTOONCOGENE EXPRESSION; PROTO-ONCOGENE; S-PHASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M. Hamon et al., "HEPARIN DOES NOT INHIBIT ONCOGENE INDUCTION IN RABBIT AORTA FOLLOWINGBALLOON DENUDATION", Cardiovascular Research, 27(7), 1993, pp. 1209-1213

Abstract

Objective: Smooth musle cell proliferation and migration are the predominant responses to intimal and medial injury after percutaneous transluminal coronary angioplasty. The in vivo inhibitory effect of heparin on these responses is well documented. To test the hypothesis that the antiproliferative effect of heparin in vivo may be related to an inhibition of proto-oncogene expression, the effects of pretreatment with heparin on the expression of the c-myc, c-fos and c-jun proto-oncogenes were examined in a rabbit model of balloon denudation. Methods: Animals were randomised 5 h before balloon denudation to receive a subcutaneous injection of unfractionated heparin (7500 IU.kg-1, n=7) or saline (n=6). Total RNA extracted from the aorta 1 h after balloon denudation was analysed by northern blot technique. A histological study wasalso performed in saline treated (n=4) and heparin treated (n=4) animals 28 d after balloon denudation. Results: The histological study showed that the degree of neointimal thickening was significantly less inheparin treated animals. However, the level of expression of the proto-oncogenes we studied was similar in both groups. Conclusions: Heparin inhibits neointimal thickening after balloon denudation. This inhibition is not associated with an overall decrease in the level of expression of the c-myc, c-fos, or c-jun proto-oncogenes in the arterial wall, suggesting that the antiproliferative effect of heparin may be due to an effect on other events in the cell cycle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:47:55