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Titolo:
TESTING SURFACTANT TREATMENT RESPONSES - A COMPARISON OF 2 MODELS
Autore:
HENRY MD; IKEGAMI M; JOBE AH;
Indirizzi:
UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,SCH MED,DEPT PEDIAT,1124 W CARSON ST,RB-1 TORRANCE CA 90502 UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,SCH MED,DEPT PEDIAT TORRANCE CA 90502
Titolo Testata:
Biology of the neonate
fascicolo: 3, volume: 71, anno: 1997,
pagine: 181 - 189
SICI:
0006-3126(1997)71:3<181:TSTR-A>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREMATURELY DELIVERED RABBITS; PRETERM LAMBS; NATURAL SURFACTANT; SYNTHETIC SURFACTANT; EXOGENOUS SURFACTANT; LUNG-FUNCTION; REPLACEMENT; VENTILATION; NEONATE; THERAPY;
Keywords:
RESPIRATORY DISTRESS SYNDROME; DYNAMIC COMPLIANCE; PRETERM LAMB; PRETERM RABBIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M.D. Henry et al., "TESTING SURFACTANT TREATMENT RESPONSES - A COMPARISON OF 2 MODELS", Biology of the neonate, 71(3), 1997, pp. 181-189

Abstract

We have compared treatment responses of two surfactants in two animalmodels of respiratory distress syndrome. Preterm rabbits at 27 days gestation and premature lambs at 126 days gestation were treated with natural sheep surfactant Survanta(R) (Ross Laboratories), or no surfactant and then were ventilated with the same ventilation style to achieve tidal volumes of 8 ml/kg. Dynamic compliances at 15 min were higher for control and surfactant-treated rabbits than for preterm lambs. Sheep surfactant and Survanta increased compliances in rabbits, but only sheep-surfactant-treated lambs had compliances higher than controls at15 min of age. Maximal lung volumes (milliliters per kilogram) of therabbits (after 15 min ventilation) were about twice those of the lambs (after 4 h of ventilation). Lung volumes of sheep-surfactant-treatedrabbits were larger than for Survanta-treated rabbits, but no differences in lung volume were evident between the surfactant-treated lambs. The two models for testing surfactants do not give the same results when directly compared.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:32:23