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Titolo:
INHIBITION OF UROKINASE SYNTHESIS AND CELL-SURFACE BINDING ALTERS THEMOTILE BEHAVIOR OF EMBRYONIC ENDOCARDIAL-DERIVED MESENCHYMAL CELLS IN-VITRO
Autore:
MCGUIRE PG; ALEXANDER SM;
Indirizzi:
UNIV NEW MEXICO,SCH MED,DEPT ANAT ALBUQUERQUE NM 87131
Titolo Testata:
Development
fascicolo: 3, volume: 118, anno: 1993,
pagine: 931 - 939
SICI:
0950-1991(1993)118:3<931:IOUSAC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR; GLYCOSYL-PHOSPHATIDYLINOSITOL; BASEMENT-MEMBRANE; ENDOTHELIAL-CELLS; TRITON X-114; GROWTH CONE; TRANSFORMATION; GLYCOPROTEIN; FIBRONECTIN; DEGRADATION;
Keywords:
UROKINASE; MESENCHYME; MIGRATION; CELL SURFACE; ENDOCARDIUM; CELL-MATRIX INTERACTION; QUAIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
P.G. Mcguire e S.M. Alexander, "INHIBITION OF UROKINASE SYNTHESIS AND CELL-SURFACE BINDING ALTERS THEMOTILE BEHAVIOR OF EMBRYONIC ENDOCARDIAL-DERIVED MESENCHYMAL CELLS IN-VITRO", Development, 118(3), 1993, pp. 931-939

Abstract

The expression of the serine protease urokinase is elevated during the epithelial-mesenchymal transformation of the endocardium in the developing avian heart. Elevated urokinase expression is associated with the migrating mesenchymal cells of the atrioventricular canal and bulbotruncus and not the myocardium. Treatment of isolated endocardial-derived mesenchymal cells with phosphatidyinositol-specific phospholipase C released urokinase and its receptor from the cell surface and causedsignificant alterations in cell morphology and motility. Likewise inhibition of urokinase synthesis by treatment of cells with antisense oligonucleotides also inhibited the migration and motility of the endocardial-derived cells. These results suggest an important role for this enzyme in cell-matrix interactions and cell migration during development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 03:12:42