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Titolo:
INCREASED NEUROPEPTIDE-Y CONCENTRATIONS IN SPECIFIC HYPOTHALAMIC NUCLEI OF THE RAT FOLLOWING TREATMENT WITH METHYSERGIDE - EVIDENCE THAT NPY MAY MEDIATE SEROTONINS EFFECTS ON FOOD-INTAKE
Autore:
DRYDEN S; MCCARTHY HD; MALABU UH; WARE M; WILLIAMS G;
Indirizzi:
UNIV LIVERPOOL,DEPT MED,POB 147 LIVERPOOL L69 3BX ENGLAND UNIV LIVERPOOL,DEPT MED,POB 147 LIVERPOOL L69 3BX ENGLAND
Titolo Testata:
Peptides
fascicolo: 4, volume: 14, anno: 1993,
pagine: 791 - 796
SICI:
0196-9781(1993)14:4<791:INCISH>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; OBESE ZUCKER RATS; MESSENGER-RIBONUCLEIC-ACID; PARAVENTRICULAR NUCLEUS; SUPRACHIASMATIC NUCLEUS; DIABETIC RATS; MACRONUTRIENT SELECTION; PEPTIDE-YY; FACTOR CRF; BRAIN;
Keywords:
NEUROPEPTIDE-Y; METHYSERGIDE; HYPOTHALAMIC NEURONS; SEROTONIN; FOOD INTAKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
S. Dryden et al., "INCREASED NEUROPEPTIDE-Y CONCENTRATIONS IN SPECIFIC HYPOTHALAMIC NUCLEI OF THE RAT FOLLOWING TREATMENT WITH METHYSERGIDE - EVIDENCE THAT NPY MAY MEDIATE SEROTONINS EFFECTS ON FOOD-INTAKE", Peptides, 14(4), 1993, pp. 791-796

Abstract

Neuropeptide Y (NPY) is a potent central appetite stimulant found in hypothalamic neurons that have close anatomical associations with neurons containing serotonin, a powerful anorectic agent. To determine whether the two neurotransmitters interact functionally, we have studied the effects on regional hypothalamic NPY concentrations of acute and chronic administration of methysergide, a 5-HT1(B)C/serotonin receptor antagonist. Chronic methysergide treatment (10 mg/kg/day) was given bysubcutaneously implanted osmotic minipumps (n = 8). Acute effects of methysergide were determined 4 h after a single injection (10 mg/kg) in a separate group (n = 8). Controls (n = 8) had implanted minipumps delivering saline, and also received a saline injection 4 h before sacrifice. Food intake was significantly increased (p < 0.01) by both acute and chronic methysergide treatment. In the chronically treated rats,NPY levels were significantly increased over controls in the arcuate nucleus (ARC; by 41%, p = 0.02) and paraventricular nucleus (PVN; by 40%, p < 0.0 1). Acute methysergide treatment also increased NPY concentrations in the ARC (by 81%, p < 0.01) and PVN (by 30%, p < 0.01). Methysergide administration, which stimulated feeding, therefore raised NPY concentrations in the ARC, where NPY is synthesized, and in the PVN, a major site of NPY release where NPY injection induces hyperphagia. These findings suggest that NPYergic and serotoninergic innervations in the hypothalamus interact to regulate food intake, and raise the possibility that increased NPY release may mediate the hyperphagic effect of serotoninergic 5-HT1(B)C/receptor blockade.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:43:23