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Titolo:
INHIBITION OF 9-ALPHA,11-BETA-PROSTAGLANDIN-F2-INDUCED BRONCHIAL HYPERRESPONSIVENESS BY THROMBOXANE-A2 RECEPTOR ANTAGONISTS IN GUINEA-PIGS
Autore:
KUROSAWA M; YODONAWA S; TSUKAGOSHI H;
Indirizzi:
GUNMA UNIV,SCH MED,DEPT INTERNAL MED 1,3-39-15 SHYOWA MACHI MAEBASHI GUNMA 371 JAPAN
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 238, anno: 1993,
pagine: 335 - 341
SICI:
0014-2999(1993)238:2-3<335:IO9BH>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN AIRWAYS; ACID 9-ALPHA,11-BETA-PROSTAGLANDIN-F2; INFLAMMATORY MEDIATORS; 11-KETO REDUCTASE; RABBIT LIVER; PROSTAGLANDIN-D2; RAT; ASTHMA; RESPONSIVENESS; METHACHOLINE;
Keywords:
BRONCHIAL HYPERRESPONSIVENESS; 9-ALPHA,11-BETA-PROSTAGLANDIN-F(2); THROMBOXANE-A(2) RECEPTOR ANTAGONISTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M. Kurosawa et al., "INHIBITION OF 9-ALPHA,11-BETA-PROSTAGLANDIN-F2-INDUCED BRONCHIAL HYPERRESPONSIVENESS BY THROMBOXANE-A2 RECEPTOR ANTAGONISTS IN GUINEA-PIGS", European journal of pharmacology, 238(2-3), 1993, pp. 335-341

Abstract

We studied the effect of intravenous administration of 9alpha,11beta-prostaglandin F2 on bronchial responsiveness to histamine and airway wall thickening in guinea pigs. The infusion of 9alpha,11beta-prostaglandin F2 induced an increase of the relative thickness of the airway wall in peripheral bronchi demonstrable by histological examination. Analysis of airway function showed that the infusion of 9alpha,11beta-prostaglandin F2 induced airway hyperresponsiveness to histamine with airway wall thickening. The thromboxane A2 receptor antagonists, ONO-NT-126 minomethyl)bicyclo-[2.2.1]heptane-2-yl]hex-5-enoic acid) and ONO-8809 minomethyl)bi-cyclo[2.2.l]hept-2-yl]-5-hexenoate), inhibited these effects of 9alpha,11beta-prostaglandin F2 in a dose-dependent manner.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 13:56:54