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Titolo:
MULTIPLE MECHANISMS OF SEROTONIN 5-HT2 RECEPTOR DESENSITIZATION
Autore:
RAHMAN S; NEUMAN RS;
Indirizzi:
MEM UNIV NEWFOUNDLAND,FAC MED ST JOHNS A1B 3V6 NEWFOUNDLAND CANADA MEM UNIV NEWFOUNDLAND,FAC MED ST JOHNS A1B 3V6 NEWFOUNDLAND CANADA
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 238, anno: 1993,
pagine: 173 - 180
SICI:
0014-2999(1993)238:2-3<173:MMOS5R>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; METHYL-D-ASPARTATE; ALTERED MEMBRANE FORM; INOSITOL TRISPHOSPHATE; PHOSPHOINOSITIDE TURNOVER; CALMODULIN ANTAGONISTS; PHOSPHOLIPASE-C; HUMAN-PLATELETS; PHORBOL ESTER; RAT-BRAIN;
Keywords:
5-HT (5-HYDROXYTRYPTAMINE, SEROTONIN); TRANSMITTER INTERACTION; DESENSITIZATION; RECEPTOR INTERNALIZATION; PROTEIN KINASE-C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
S. Rahman e R.S. Neuman, "MULTIPLE MECHANISMS OF SEROTONIN 5-HT2 RECEPTOR DESENSITIZATION", European journal of pharmacology, 238(2-3), 1993, pp. 173-180

Abstract

Desensitization of serotonin 5-HT2 receptor-mediated enhancement of the N-methyl-D-aspartate (NMDA) depolarization was studied in rat cortical neurons. Serotonin and +/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) induced long term desensitization. Staurosporine, a nonspecific protein kinase C inhibitor, potentiated the serotonin and DOI facilitation, suggesting acute desensitization was operative. In the case of DOI, long term desensitization was prevented by staurosporine. Activators of protein kinase C abolished the serotonin facilitation, an action prevented by staurosporine. Concanavalin A potentiated the facilitation at 100 muM, but not 30 muM serotonin, suggesting these receptors undergo dose dependent internalization. Calmodulin antagonists prevent long term desensitization induced by serotonin. The depolarization induced by NMDA alone was not altered by staurosporine, protein kinase C activators, concanavalin A or calmodulin antagonists. Serotoninat 100 muM, but not 30 muM, induced heterologous desensitization of phenylephrine and carbachol induced facilitation of the NMDA depolarization. We conclude that serotonin 5-HT2 receptors both induce and undergo several forms of desensitization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 02:23:01