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Titolo:
A PLEIOTROPIC REDUCED VIRULENCE (RVI-) MUTANT OF ERWINIA-CAROTOVORA SUBSPECIES ATROSEPTICA IS DEFECTIVE IN FLAGELLA ASSEMBLY PROTEINS THAT ARE CONSERVED IN PLANT AND ANIMAL BACTERIAL PATHOGENS
Autore:
MULHOLLAND V; HINTON JCD; SIDEBOTHAM J; TOTH IK; HYMAN LJ; PEROMBELON MCM; REEVES PJ; SALMOND GPC;
Indirizzi:
UNIV WARWICK,DEPT BIOL SCI COVENTRY CV4 7AL W MIDLANDS ENGLAND UNIV WARWICK,DEPT BIOL SCI COVENTRY CV4 7AL W MIDLANDS ENGLAND SCOTTISH CROP RES INST DUNDEE DD2 5DA SCOTLAND
Titolo Testata:
Molecular microbiology
fascicolo: 2, volume: 9, anno: 1993,
pagine: 343 - 356
SICI:
0950-382X(1993)9:2<343:APRV(M>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SALMONELLA-TYPHIMURIUM; PSEUDOMONAS-SYRINGAE; TRANSPOSON MUTAGENESIS; XANTHOMONAS-CAMPESTRIS; SEQUENCE-ANALYSIS; HYPERSENSITIVE RESPONSE; NUCLEOTIDE-SEQUENCES; AVIRULENT MUTANTS; ESCHERICHIA-COLI; BACTERIOPHAGE-MU;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
V. Mulholland et al., "A PLEIOTROPIC REDUCED VIRULENCE (RVI-) MUTANT OF ERWINIA-CAROTOVORA SUBSPECIES ATROSEPTICA IS DEFECTIVE IN FLAGELLA ASSEMBLY PROTEINS THAT ARE CONSERVED IN PLANT AND ANIMAL BACTERIAL PATHOGENS", Molecular microbiology, 9(2), 1993, pp. 343-356

Abstract

Erwinia carotovora subsp. atroseptica was mutagenized and assayed forvirulence in planta. Those mutants which exhibited reduced virulence (Rvi-) were assayed for growth rate, auxotrophy and extracellular enzyme secretion and seven mutants were found to be wild type for all of these phenotypes. When screened for other phenotypes, two were found tobe non-motile. One mutant was complemented for motility by a heterologous gene library. A 2.7 kb XmaIII-ClaI complementing fragment was sequenced and the gene products were found to have similarity to flagellabiosynthesis gene products from several bacteria. Further similarity was found to a pathogenicity protein from the plant pathogen Xanthomonas campestris pv. glycines and to the Spa pathogenicity proteins of the human pathogen Shigella flexneri, which are involved in the surface presentation of antigens. These studies highlight the emergence of common themes in the molecular strategies employed by both plant and animal bacterial pathogens for the targeting of proteins involved in the elaboration of disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:20:37