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Titolo:
DIFFERENTIATION OF INODILATORY RESPONSES BY NONINVASIVE MEASURES OF CARDIOVASCULAR PERFORMANCE IN HEALTHY MAN
Autore:
DEMEY C; ERB K; SCHROETER V; BELZ GG;
Indirizzi:
IPHAR,INST CLIN PHARMACOL,POB 1165 D-85635 HOHENKIRCHEN GERMANY UNIV ERLANGEN NURNBERG,DEPT EXPT & CLIN PHARMACOL & TOXICOL D-8520 ERLANGEN GERMANY CTR CARDIOVASC PHARMACOL MAINZ GERMANY
Titolo Testata:
International journal of clinical pharmacology and therapeutics
fascicolo: 12, volume: 34, anno: 1996,
pagine: 525 - 532
SICI:
0946-1965(1996)34:12<525:DOIRBN>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTOLIC-TIME INTERVALS; PRE-EJECTION PERIOD; CLINICAL-PHARMACOLOGY; IMPEDANCE CARDIOGRAPHY; BLOCKING PROPERTIES; VOLUNTEERS; ECHOCARDIOGRAPHY; BISOPROLOL; CELIPROLOL; DIGITOXIN;
Keywords:
INODILATION; ADRENALINE; ISOPRENALINE; BIMAKALIM; CELIPROLOL; PHOSPHODIESTERASE INHIBITION; IMPEDANCE CARDIOGRAPHY; SYSTOLIC TIME INTERVALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
C. Demey et al., "DIFFERENTIATION OF INODILATORY RESPONSES BY NONINVASIVE MEASURES OF CARDIOVASCULAR PERFORMANCE IN HEALTHY MAN", International journal of clinical pharmacology and therapeutics, 34(12), 1996, pp. 525-532

Abstract

The cardiovascular responses to various inodilatory interventions were investigated noninvasively in healthy man by monitoring heart rate (HR), blood pressure (SBP/DBP, according to Korotkoff I and IV criteria), systolic time intervals (PEP, VET and QS2) and impedance cardiographic estimates of stroke volume (SV) and cardiac output (CO). The following inodilatory interventions were evaluated and compared: the i.v. infusion of adrenaline (1 mu g/min), the i.v. infusion of isoprenaline (1 mu g/min) with and without pretreatment with 100 mg talinolol (a beta-selective beta-adrenoceptor antagonist), the p.o. administration of1200 mg celiprolol (a beta(1)-adrenoceptor antagonist with ancillary beta-adrenergic agonistic properties at the chosen dose level), the p.o. administration of 0.4 mg bimakalim (a K+ channel activator without direct cardiac effect) with and without pretreatment with 5 mg bisoprolol and the p.o. administration of the PDE-III inhibitors meribendan and isomazole. The extent of the inodilatory rise of HR, shortening of PEP, rise of SV and CO relative to the associated reduction of the calculated total peripheral resistance (TPR) proved a powerful tool to differentiate inodilatory properties: adrenaline, isoprenaline after beta-selective beta -adrenoceptor blockade and celiprolol led to similar ancillary adrenaline-like cardiovascular changes relative to the vasodilatation; bimakalim led to similar associated changes except for a relatively larger rise of HR, which could be blocked by bisoprolol; isoprenaline induced clearly larger associated changes, for which HR, VET,and QS2c were particularly sensitive; meribendan and isomazole resulted in the largest ancillary changes, characterized by a critical shortening of the ejection time VET, so that the rise of CO was almost exclusively defined by the rise of HR. These differences could be detectedand differentiated sufficiently and adequately by HR, SV, CO, TPR, PEP, and VET. There seems little value in using more assumptive variables such as HR-corrected VETc and QS2c, the Weissler index and the impedance cardiographic Heather index.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 06:55:36