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Titolo:
EXPRESSION OF THE CYSTIC-FIBROSIS GENE AND THE MAJOR PANCREATIC MUCINGENE, MUC1, IN HUMAN DUCTAL EPITHELIAL-CELLS
Autore:
CHAMBERS JA; HARRIS A;
Indirizzi:
JOHN RADCLIFFE HOSP,INST MOLEC MED OXFORD OX3 9DU ENGLAND
Titolo Testata:
Journal of Cell Science
, volume: 105, anno: 1993,
parte:, 2
pagine: 417 - 422
SICI:
0021-9533(1993)105:<417:EOTCGA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSMEMBRANE CONDUCTANCE REGULATOR; HUMAN-FETAL PANCREAS; MOLECULAR-CLONING; CHLORIDE CHANNEL; LINE; DIFFERENTIATION; LOCALIZATION; CARCINOMA; MODEL; CFTR;
Keywords:
CFTR; MUC1; DUCTAL EPITHELIAL CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Chambers e A. Harris, "EXPRESSION OF THE CYSTIC-FIBROSIS GENE AND THE MAJOR PANCREATIC MUCINGENE, MUC1, IN HUMAN DUCTAL EPITHELIAL-CELLS", Journal of Cell Science, 105, 1993, pp. 417-422

Abstract

The main pathology of cystic fibrosis results from obstruction of ducts in several organs by mucous secretions. The cause of this obstruction remains unclear. We have examined expression of the cystic fibrosistransmembrane conductance regulator (CFTR) and of the major pancreatic mucin, MUC1, in primary pancreatic duct and vas deferens epithelial cells, and in pancreatic duct cell lines. MUC1 is expressed at a high level in the primary ductal epithelial cells and at variable levels indifferent pancreatic adenocarcinoma cell lines. However, although thepancreatic duct is one of the sites in vivo where CFTR transcription is at its highest level, the majority of cell lines examined no longerexpress CFTR. Only one pancreatic duct cell line, Capan 1, expresses CFTR at a significant level; further, the level of expression is dependent on confluency. We have shown that salt stress alone is not sufficient to account for the build-up of mucous secretions in CF ducts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 20:53:24