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Titolo:
REGIONAL PATTERNS OF CHOLINERGIC AND GLUTAMATE ACTIVITY IN THE DEVELOPING AND AGING HUMAN BRAIN
Autore:
COURT JA; PERRY EK; JOHNSON M; PIGGOTT MA; KERWIN JA; PERRY RH; INCE PG;
Indirizzi:
NEWCASTLE GEN HOSP,MRC,NEUROCHEM PATHOL UNIT,WESTGATE RD NEWCASTLE TYNE NE4 6BE TYNE & WEAR ENGLAND NEWCASTLE GEN HOSP,DEPT NEUROPATHOL NEWCASTLE TYNE NE4 6BE TYNE & WEAR ENGLAND
Titolo Testata:
Developmental brain research
fascicolo: 1, volume: 74, anno: 1993,
pagine: 73 - 82
SICI:
0165-3806(1993)74:1<73:RPOCAG>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; NERVOUS-SYSTEM DEVELOPMENT; D-ASPARTATE RECEPTORS; ALZHEIMERS-DISEASE; BINDING-SITES; AUTORADIOGRAPHIC LOCALIZATION; ORNITHINE DECARBOXYLASE; CEREBELLAR CORTEX; FRONTAL-CORTEX; PURKINJE-CELLS;
Keywords:
CHOLINE ACETYLTRANSFERASE; ACETYLCHOLINESTERASE; MK-801; LPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; DEVELOPMENT; AGING; HUMAN BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Court et al., "REGIONAL PATTERNS OF CHOLINERGIC AND GLUTAMATE ACTIVITY IN THE DEVELOPING AND AGING HUMAN BRAIN", Developmental brain research, 74(1), 1993, pp. 73-82

Abstract

The levels of choline acetyltransferase (ChAT) and the binding activity of N-methyl-D-aspartate (NMDA) and non-NMDA receptors have been measured in the hippocampus, entorhinal cortex, frontal cortex and cerebellum, in a series of human brains from 24 weeks gestation to 100 years. The patterns of ChAT and glutamate receptor activity during aging and development were strikingly different in the different brain areas. In the hippocampus and associated cortex, ChAT activity did not reach a peak until middle age, when it almost immediately started to declineby 50-60% to the 10th decade, whereas in the frontal cortex ChAT peaked transiently in the infant and then stayed constant during aging. Inthe cerebellum ChAT activity was very high in the foetus and fell in the neonate to maintain a constant level more in line with the concentrations found in the other brain areas through the rest of life. The high levels of ChAT in the foetal cerebellum were not associated with high acetylcholinesterase (AChE) content, which tended to increase during development, and was present initially in Purkinje cells (foetus and neonate) and the molecular layer in the adult. In the hippocampus and entorhinal cortex, autoradiographic [H-3]MK-801 binding was relatively constant throughout life, however, [H-3]CNQX binding rose from the perinatal period up to a peak in the lst or 2nd decade and then tendedto fall with age. In the cerebellum, autoradiographic binding of bothligands rose from the foetal period to reach a plateau by the age of 10 years and there was no apparent further change during aging. These data on cholinergic and glutamatergic phenotypic changes during development and senescence reflect marked variations in regional plasticity and aging within and between the two transmitter systems and are likely to contribute to our understanding of their role in the different brain areas investigated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 20:31:55