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Titolo:
INVOLVEMENT OF D(2) DOPAMINERGIC RECEPTORS IN THE EMOTIONAL AND MOTIVATIONAL RESPONSES INDUCED BY INJECTION OF CCK-8 IN THE POSTERIOR PART OF THE RAT NUCLEUS-ACCUMBENS
Autore:
DERRIEN M; DURIEUX C; DAUGE V; ROQUES BP;
Indirizzi:
UNIV PARIS 05,UFR SCI PHARMACEUT & BIOL,CNRS,URA D1500,INSERM F-75270PARIS 06 FRANCE UNIV PARIS 05,UFR SCI PHARMACEUT & BIOL,CNRS,URA D1500,INSERM F-75270PARIS 06 FRANCE
Titolo Testata:
Brain research
fascicolo: 2, volume: 617, anno: 1993,
pagine: 181 - 188
SICI:
0006-8993(1993)617:2<181:IODDRI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
JAW MOVEMENTS; CHOLECYSTOKININ OCTAPEPTIDE; ANESTHETIZED RAT; CAUDAL PART; RELEASE; NEURONS; 6-HYDROXYDOPAMINE; ANTAGONISTS; NEUROTENSIN; MODULATION;
Keywords:
CCK-8 DA INTERACTION; RAT; POSTERIOR NUCLEUS ACCUMBENS; DOPAMINE; D(1), D(2) DOPAMINE RECEPTOR; BEHAVIOR; EMOTIONAL AND MOTIVATIONAL STATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
M. Derrien et al., "INVOLVEMENT OF D(2) DOPAMINERGIC RECEPTORS IN THE EMOTIONAL AND MOTIVATIONAL RESPONSES INDUCED BY INJECTION OF CCK-8 IN THE POSTERIOR PART OF THE RAT NUCLEUS-ACCUMBENS", Brain research, 617(2), 1993, pp. 181-188

Abstract

When CCK-8 was injected in the rat posterior nucleus accumbens, whereit is in part co-localized with dopamine, a decrease in exploration of the four hole box and the elevated plus maze was observed. In this study, a selective destruction of the dopaminergic mesoaccumbens pathway induced by local injection of 6-hydroxydopamine (6-OHDA) in the nucleus accumbens was found to suppress the CCK-8-evoked behavioral effects. Moreover, an ex vivo measurement of the dopaminergic metabolism hasbeen performed after injection of CCK-8 in the posterior nucleus accumbens by electrochemical detection of dopamine and its metabolites extracted from punches of brain tissue. The results showed that CCK-8 decreased the turnover of dopamine in the posterior part but not in the anterior part of the nucleus accumbens or in the ventral tegmental area. Furthermore, sulpiride, a selective antagonist for D2 dopamine receptors, but not SCH 23390, a selective antagonist for D1 dopamine receptors, prevented CCK-8-induced behavioral responses. Taken together, these results suggest that CCK-8 could be involved in behavioral adaptation to situations producing change in emotional and/or motivational states through modulation of presynaptic D2 receptor functioning.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 06:21:18