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Titolo:
ANTISENSE NUCLEIC-ACIDS - PROSPECTS FOR ANTIVIRAL INTERVENTION
Autore:
TONKINSON JL; STEIN CA;
Indirizzi:
COLUMBIA UNIV COLL PHYS & SURG,DEPT MED,630 W 168 ST NEW YORK NY 10032
Titolo Testata:
Antiviral chemistry & chemotherapy
fascicolo: 4, volume: 4, anno: 1993,
pagine: 193 - 200
SICI:
0956-3202(1993)4:4<193:AN-PFA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; HERPES-SIMPLEX VIRUS; CHRONICALLY INFECTED-CELLS; PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDES; GENE-EXPRESSION; DEXTRAN SULFATE; INHIBITION; OLIGONUCLEOTIDES; REPLICATION; DNA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Tonkinson e C.A. Stein, "ANTISENSE NUCLEIC-ACIDS - PROSPECTS FOR ANTIVIRAL INTERVENTION", Antiviral chemistry & chemotherapy, 4(4), 1993, pp. 193-200

Abstract

Antisense oligodeoxynucleotides are a promising new class of antiviral agent. Because they bind in a sequence-specific manner to complementary regions of mRNA, oligos can inhibit gene expression in a sequence-specific manner. The 'antisense' approach has been used successfully to block cellular expression and replication of several viruses including Human Immunodeficiency Virus-1 (HIV-1), and Herpes Simplex Virus (HSV). However, the antiviral effect of oligodeoxynucleotides is not limited to sequence-specific inhibition of gene expression. Non sequence-specific effects are frequently observed, presumably as a result of their properties as polyanions. Occasionally (e.g. for HIV-1) these non sequence-specific effects are also therapeutic. The prospects for antisense oligodeoxynucleotide therapy for viral disease are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:00:36