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Titolo:
A COMPARATIVE-STUDY ON THE ROLE PLAYED BY MUCUS GLYCOPROTEINS IN THE RHEOLOGICAL BEHAVIOR OF THE MUCOADHESIVE MUCOSAL INTERFACE
Autore:
MORTAZAVI SA; CARPENTER BG; SMART JD;
Indirizzi:
UNIV PORTSMOUTH,SCH PHARM & BIOMED SCI,DRUG DELIVERY RES UNIT PORTSMOUTH PO1 2DZ ENGLAND UNIV PORTSMOUTH,SCH PHARM & BIOMED SCI,DRUG DELIVERY RES UNIT PORTSMOUTH PO1 2DZ ENGLAND
Titolo Testata:
International journal of pharmaceutics
fascicolo: 1-3, volume: 94, anno: 1993,
pagine: 195 - 201
SICI:
0378-5173(1993)94:1-3<195:ACOTRP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROGELS; DELIVERY; SYSTEMS;
Keywords:
MUCOADHESION; BIOADHESION; MUCOSAL ADHESION; MUCUS GLYCOPROTEIN; BIORHEOLOGY; POLYACRYLIC ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Mortazavi et al., "A COMPARATIVE-STUDY ON THE ROLE PLAYED BY MUCUS GLYCOPROTEINS IN THE RHEOLOGICAL BEHAVIOR OF THE MUCOADHESIVE MUCOSAL INTERFACE", International journal of pharmaceutics, 94(1-3), 1993, pp. 195-201

Abstract

One proposed mechanism of mucoadhesion involves the interpenetration of the mucus/mucoadhesive molecules followed by the formation of non-covalent interactions. Mucus glycoproteins are believed to be the majorstructure forming component of mucus, giving rise to the cohesive andthe viscoelastic nature of the mucus gel. The addition of a known mucoadhesive, the polyacrylic acid Carbopol 934P (paa), to purified mucusglycoprotein resulted in the formation of a strengthened gel network. This was indicated on visual examination, and also on rheological examination using mechanical spectroscopy. A large mean G' (the storage modulus, found between 10 and 0.1 HZ) was obtained for the glycoprotein/paa mix in comparison to when the glycoprotein and paa gels were tested separately at the same concentration. Similar results were obtainedwith crude and homogenised mucus samples. This gel strengthening phenomena was optimum at pH values around the pK(a) of paa. It was concluded that it is the glycoprotein component of mucus which interacts withpaa to produce gel strengthening, and this may increase the cohesive nature of the weakest component of a mucoadhesive joint, thus allowingprolonged mucosal adhesion. A rheological investigation of a pH 6.2 glycoprotein/paa mix between 10 and 0.002 Hz indicated that this gel strengthening effect resulted from both chain entanglement and the formation of secondary chemical bonds.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 20:00:13