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Titolo:
CAPTOPRIL RADIONUCLIDE TEST IN RENOVASCULAR HYPERTENSION - A EUROPEANMULTICENTER STUDY
Autore:
FOMMEI E; GHIONE S; HILSON AJW; MEZZASALMA L; OEI HY; PIEPSZ A; VOLTERRANI D;
Indirizzi:
CNR,INST CLIN PHYSIOL,MULTICTR STUDY CENT OFF,VIA P SAVI 8 I-56100 PISA ITALY
Titolo Testata:
European journal of nuclear medicine
fascicolo: 7, volume: 20, anno: 1993,
pagine: 617 - 623
SICI:
0340-6997(1993)20:7<617:CRTIRH>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-ARTERY STENOSIS; GLOMERULAR-FILTRATION RATE; DIAGNOSIS; SCINTIGRAPHY; RENOGRAPHY;
Keywords:
CAPTOPRIL RENOGRAPHY; RENOVASCULAR HYPERTENSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
E. Fommei et al., "CAPTOPRIL RADIONUCLIDE TEST IN RENOVASCULAR HYPERTENSION - A EUROPEANMULTICENTER STUDY", European journal of nuclear medicine, 20(7), 1993, pp. 617-623

Abstract

The diagnostic work-up of renovascular hypertension is still controversial. The efficacy of renal scintigraphy with technetium-99m diethylene triamine penta-acetate (DTPA) before and after captopril (scintigraphic captopril test) was evaluated in a multicentre study. All 380 hypertensive patients in the study underwent renal arteriography; 125 hadrenal arterial stenosis greater-than-or-equal-to 70%, and 54 had a technically successful intervention to correct the stenosis. The post-captopril study had a sensitivity of 93% and a specificity of 100% for predicting blood pressure response to intervention, if renal function was normal and a combination of quantitative parameters was applied (individual kidney uptake index < 40 %, time to peak activity < 2 min or > 10 min). In the entire population renal artery stenosis greater-than-or-equal-to 70% was detected with a sensitivity of 83% and a specificity of 93% if renal function was normal. In patients with abnormal renal function the performance of the test was worse, owing to a lower specificity which could be increased by using only time parameters. The performance of the test was optimal when the post-captopril findings were examined; no improvement was achieved by evaluation of the changesinduced by captopril from the baseline. The test can thus be simplified by performing only a post-captopril study for routine use: a negative test would exclude a curable form of renovascular hypertension in >80% and a positive test would predict it in > 90% of the patients selected for suspicion of the disease. Usefulness of the scintigraphic test for monitoring the clinical results of intervention is suggested bycorrelating post-intervention outcome with pre- and post-interventionscintigraphic results.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:38:58