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Titolo:
EFFECTS OF ADJUVANTS AND MULTIPLE ANTIGEN PEPTIDES ON HUMORAL AND CELLULAR IMMUNE-RESPONSES TO GP160 OF HIV-1
Autore:
LEVI M; RUDEN U; BIRX D; LOOMIS L; REDFIELD R; LOVGREN K; AKERBLOM L; SANDSTROM E; WAHREN B;
Indirizzi:
NATL BACTERIOL LAB,DEPT VIROL S-10521 STOCKHOLM SWEDEN WALTER REED ARMY INST RES ROCKVILLE MD 00000 NATL VET INST,DEPT VIROL UPPSALA SWEDEN VENHALSAN,SOUTH HOSP STOCKHOLM SWEDEN
Titolo Testata:
Journal of acquired immune deficiency syndromes
fascicolo: 8, volume: 6, anno: 1993,
pagine: 855 - 864
SICI:
0894-9255(1993)6:8<855:EOAAMA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; CYTOTOXIC T-CELLS; SYNTHETIC PEPTIDES; ENVELOPE PROTEIN; MONOCLONAL-ANTIBODIES; MEDIATED-IMMUNITY; AMINO-ACIDS; B-CELL; GP120; IMMUNIZATION;
Keywords:
HIV-1; ADJUVANTS; GP160; MAP; V3 REGION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
M. Levi et al., "EFFECTS OF ADJUVANTS AND MULTIPLE ANTIGEN PEPTIDES ON HUMORAL AND CELLULAR IMMUNE-RESPONSES TO GP160 OF HIV-1", Journal of acquired immune deficiency syndromes, 6(8), 1993, pp. 855-864

Abstract

The capacity of five different adjuvants, AlPO4, a muramyldipeptide formulation (MDP.TSL), Freund's adjuvant, immunostimulating complex andits matrix components to elicit humoral and cellular responses in rabbits immunized with the human immunodeficiency virus type 1 (HIV-1) envelope protein rgp160IIIB was compared. The highest antibody titers against gp160 and gp41/gp120 epitopes were seen with rgp160 in MDP.TSL or Freund's adjuvant, whereas the broadest responses were seen in rabbits immunized with rgp160 in matrix or MDP.TSL. The broadest spectrum of high-avidity antibodies was also induced by rgp160 in MDP.TSL. Neutralizing titers against HIV-1IIIB, low titers to HIV-1MN, and the most efficient inhibition of viral cell-to-cell spread was seen with rgp160in MDP.TSL. The strongest and most persisting cellular responses wereinduced by rgp160 in AlPO4 or MDP.TSL. Using MDP.TSL as the adjuvant,we also improved the immune response against gp120 epitopes by boosting rgp160-primed rabbits with rgp160, multiple antigenic peptides (MAPs), or unconjugated peptides. The MAPs induced high neutralizing titers and were superior to rgp160 alone in inducing both humoral and cellular reactivity. MAPs are therefore strong candidates for inclusion into future HIV-1 vaccines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 04:40:34