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Titolo:
LACTATE-DEHYDROGENASE ACTIVITY AND ISOFORM DISTRIBUTION IN THE RAT URINARY-BLADDER - EFFECTS OF OUTLET OBSTRUCTION AND ITS REMOVAL
Autore:
POLYANSKA M; ARNER A; MALMQUIST U; UVELIUS B;
Indirizzi:
UNIV LUND HOSP,DEPT UROL S-22185 LUND SWEDEN LUND UNIV,DEPT UROL S-22101 LUND SWEDEN LUND UNIV,DEPT PHYSIOL S-22101 LUND SWEDEN LUND UNIV,DEPT BIOPHYS S-22101 LUND SWEDEN
Titolo Testata:
The Journal of urology
fascicolo: 2, volume: 150, anno: 1993,
parte:, 1
pagine: 543 - 545
SICI:
0022-5347(1993)150:2<543:LAAIDI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFRAVESICAL OUTFLOW OBSTRUCTION; HYPERTROPHIC SMOOTH-MUSCLE; AEROBIC GLYCOLYSIS; GLUCOSE-METABOLISM; CELL HYPERTROPHY; HYPERPLASIA; TISSUE; VEINS;
Keywords:
BLADDER; RATS; HYPERTROPHY; LACTATE DEHYDROGENASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
M. Polyanska et al., "LACTATE-DEHYDROGENASE ACTIVITY AND ISOFORM DISTRIBUTION IN THE RAT URINARY-BLADDER - EFFECTS OF OUTLET OBSTRUCTION AND ITS REMOVAL", The Journal of urology, 150(2), 1993, pp. 543-545

Abstract

The rat urinary bladder responded to infravesical obstruction by an increased weight. The weight began to increase after 3 days of obstruction. After 10 days the weight gain had become significant, but increased further with time. At 90 days the bladders weighed 12 times the initial weight. Lactate dehydrogenase (LDH) activity per unit bladder weight increased with the duration of the obstruction. The increase was significant in the 90 day group. The isoform pattern of LDH was determined. For the control group the M3H form was dominant, with M4 second; M4 became the dominant isoform after 3 days of obstruction, The relative amount of M4 had increased by 80% after 90 days. In one group, which was first obstructed for 10 days and then had the obstruction removed for 4 weeks, bladder weight and LDH isoform pattern were normal. We suggest that the changes in isoform pattern in the obstructed bladder reflect a metabolic adaptation to the prolonged voiding time and the increased detrusor pressure, with a consequently compromised oxygen supply, and that the changes are reversible if the outlet conditions are normalized.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 14:44:08