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Titolo:
DYNAMICS OF FUNCTIONAL CONNECTIVITY IN VISUAL CORTICAL NETWORKS - AN OVERVIEW
Autore:
FREGNAC Y;
Indirizzi:
CNRS,INST ALFRED FESSARD,EQUIPE COGNISCI,1 AVE TERRASSE F-91198 GIF SUR YVETTE FRANCE
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 3-4, volume: 90, anno: 1996,
pagine: 113 - 139
SICI:
0928-4257(1996)90:3-4<113:DOFCIV>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; CALMODULIN KINASE-II; EXCITATORY POSTSYNAPTIC POTENTIALS; DEPOLARIZING CURRENT PULSES; RECEPTIVE-FIELD DYNAMICS; SYNAPTIC PLASTICITY; ORIENTATION SELECTIVITY; OCULAR DOMINANCE; MUTANT MICE; AREA CA1;
Keywords:
FUNCTIONAL CONNECTIVITY; SYNAPTIC PLASTICITY; VISUAL CORTICAL NETWORKS; LEARNING RULES; EPIGENESIS; CORTICAL DYNAMICS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
183
Recensione:
Indirizzi per estratti:
Citazione:
Y. Fregnac, "DYNAMICS OF FUNCTIONAL CONNECTIVITY IN VISUAL CORTICAL NETWORKS - AN OVERVIEW", J PHYSL-PAR, 90(3-4), 1996, pp. 113-139

Abstract

The aim of the Royaumont Symposium was to review various dynamic aspects of adaptive changes in functional connectivity, expressed in conical networks during development, learning, and possibly during recognition and cognitive processing. The link between the various experimental and theoretical models was the comparison of cellular and molecular mechanisms that could be involved in the up- and down-regulation of functional. connectivity, over different time scales. These processes have been investigated using several approaches in parallel: 1) at the molecular/subcellular level, to identify postsynaptic receptors (NMDA, mGluR) and second messengers (calcium, protein kinases and phosphatases) involved in the induction of synaptic potentiation and depression, and to characterize diffusible factors (NO), released pre- or postsynaptically, involved in the spatial generalization of local changes to neighboring synapses; 2) at the level of integrating networks, to develop electrophysiological (single and multiple recording), pharmacological and optical imaging techniques in order to compare the dynamics of adaptive processes put into play during the natural development of cortical specificity and connectivity, versus those triggered during forced regimes of temporal correlations between pre- and post synaptic activities. Both in vitro and in vivo approaches have been combined in the primary visual cortex of the developing and adult vertebrate (rat, guinea-pig, ferret, cat and monkey). The various forms of 'slow' synaptic plasticity, demonstrated during epigenesis and selective phases of learning in the adult, can be compared with 'fast' Forms of functionalcoupling (or synchronous firing) shown to develop during the time span required for perception and cognitive processing. Phenomenology of the dynamics in functional connectivity and their relative dependence on temporal correlation in neuronal activity have been analyzed in eachof these situations. Experimental results have been compared at different levels of neuronal integration (synapse, column, map and cell assembly) in order to gain a better understanding of functional grouping within cortical networks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:10:10