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Titolo:
CYTOKINE REGULATION OF T-CELL FUNCTION - POTENTIAL FOR THERAPEUTIC INTERVENTION
Autore:
POWRIE F; COFFMAN RL;
Indirizzi:
DNAX RES INST MOLEC & CELLULAR BIOL INC,MOLEC CELLULAR BIOL RES INST,901 CALIF AVE PALO ALTO CA 94304
Titolo Testata:
Trends in pharmacological sciences
fascicolo: 5, volume: 14, anno: 1993,
pagine: 164 - 168
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; TUMOR-NECROSIS-FACTOR; INTERFERON-GAMMA; IFN-GAMMA; LYMPHOCYTE-T; B-CELLS; DOWN-REGULATION; HUMAN TH1; SUBSETS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
F. Powrie e R.L. Coffman, "CYTOKINE REGULATION OF T-CELL FUNCTION - POTENTIAL FOR THERAPEUTIC INTERVENTION", Trends in pharmacological sciences, 14(5), 1993, pp. 164-168

Abstract

CD4+ T cells, via the cytokines that they produce, play a pivotal role in the induction and regulation of cell-mediated and humoral immunity. Recently it has become clear that the CD4+ T-cell population is heterogeneous and that distinct CD4+ T-cell subsets, defined by their cytokine repertoire, regulate cell-mediated and humoral immune responses. Protective responses to pathogens are dependent on activation of the appropriate T(H) subset accompanied by its characteristic set of immune effector functions. Evidence to date suggests that the cytokines produced by the T(H) cells themselves are important regulators of T(H) subset activation and differentiation. Fiona Powrie and Robert Coffman discuss how manipulation of the levels of these cytokines can be used to alter the balance of T(H)-cell subsets and illustrate some clinical situations where this may be beneficial.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 05:36:09