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Titolo:
THE EFFECT OF NICOTINIC-ACID AND ACIPIMOX ON LIPOPROTEIN(A) CONCENTRATION AND TURNOVER
Autore:
SEED M; OCONNOR B; PEROMBELON N; ODONNELL M; REAVELEY D; KNIGHT BL;
Indirizzi:
CHARING CROSS HOSP,DEPT MED,FULHAM PALACE RD LONDON W6 8RF ENGLAND CHARING CROSS & WESTMINSTER MED SCH,DEPT MED LONDON ENGLAND HAMMERSMITH HOSP,MRC,LIPOPROT TEAM LONDON W12 0HS ENGLAND CHARING CROSS & WESTMINSTER MED SCH,DEPT CHEM PATHOL LONDON ENGLAND
Titolo Testata:
Atherosclerosis
fascicolo: 1, volume: 101, anno: 1993,
pagine: 61 - 68
SICI:
0021-9150(1993)101:1<61:TEONAA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LP(A) GLYCOPROTEIN PHENOTYPES; CHOLESTEROL; SERUM; ATHEROSCLEROSIS; REDUCTION; NIACIN; PLASMA;
Keywords:
LIPOPROTEIN LP (A); NICOTINIC ACID; IN-VIVO TURNOVER; APO(A) ISOFORMS; ACIPIMOX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M. Seed et al., "THE EFFECT OF NICOTINIC-ACID AND ACIPIMOX ON LIPOPROTEIN(A) CONCENTRATION AND TURNOVER", Atherosclerosis, 101(1), 1993, pp. 61-68

Abstract

This study examines the effect of nicotinic acid (1 g t.d.s.) on serum Lp(a) concentration in a group of patients with type II hyperlipidaemia selected on the basis of a plasma Lp(a) concentration greater than30 mg/dl. Reductions in total cholesterol, triglyceride, LDL-cholesterol and Lp(a) were 16.3%, 25.5%, 23.7% and 36.4%, respectively, with an increase in HDL cholesterol of 37.3%. The reduction in Lp(a) concentration did not correlate with any other lipoprotein changes. In order to establish the mechanism of the fall in Lp(a) concentration, in vivoturnover of autologous Lp(a) was studied in three subjects before andwhilst taking nicotinic acid. The fractional catabolic rate in Lp(a) was unaltered in the subjects on therapy, indicating that nicotinic acid did not increase catabolism of Lp(a) but decreased the synthetic rate. Since nicotinic acid was poorly tolerated we examined the effect of acipimox, an analogue of nicotinic acid on lipoproteins using a placebo controlled double-blind crossover design in a group of hyperlipidaemic patients again selected with plasma Lp(a) concentration greater than 30 mg/dl. Acipimox was better tolerated than nicotinic acid but the percentage changes in lipoprotein concentrations were smaller.

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Documento generato il 04/12/20 alle ore 13:02:21