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Titolo:
GENERAL-APPROACH TO CORRECTION FOR BIAS IN ANALYTICAL PERFORMANCE IN LONGITUDINAL-STUDIES ILLUSTRATED BY ESTIMATING THE EFFECT OF AGE ON GAMMA-GLUTAMYL-TRANSFERASE ACTIVITY
Autore:
VANDERMEULEN EA; VANSITTERT NJ; DEKONINGH AGJ; LUGTENBURG D; VANSTRIK R;
Indirizzi:
SHELL INT PETR MAATSCHAPPIJ BV,DIV HLTH SAFETY & ENVIRONM 2501 AN THEHAGUE NETHERLANDS SHELL INT PETR MAATSCHAPPIJ BV,DIV HLTH SAFETY & ENVIRONM 2501 AN THEHAGUE NETHERLANDS SHELL NEDERLAND RAFFINADERIJ BV SHELL NEDERLAND CHEM BV,DEPT OCCUPAT HLTH ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,SCH MED,DEPT EPIDEMIOL & BIOSTAT 3000 DR ROTTERDAM NETHERLANDS
Titolo Testata:
Clinical chemistry
fascicolo: 7, volume: 39, anno: 1993,
pagine: 1375 - 1381
SICI:
0009-9147(1993)39:7<1375:GTCFBI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUALITY-CONTROL; REFERENCE INTERVALS; NETHERLANDS; POPULATION; OBESITY; SYSTEM;
Keywords:
INTRAINDIVIDUAL VARIATION; AGE-RELATED EFFECTS; ENZYME ACTIVITY; VARIATION, SOURCE OF; MULTIPLE REGRESSION ANALYSIS; LONGITUDINAL VS CROSS-SECTIONAL STUDIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
E.A. Vandermeulen et al., "GENERAL-APPROACH TO CORRECTION FOR BIAS IN ANALYTICAL PERFORMANCE IN LONGITUDINAL-STUDIES ILLUSTRATED BY ESTIMATING THE EFFECT OF AGE ON GAMMA-GLUTAMYL-TRANSFERASE ACTIVITY", Clinical chemistry, 39(7), 1993, pp. 1375-1381

Abstract

For studying trends in blood biochemistry analytes of an individual or a group of individuals, the outcome may be influenced by analytical changes that may have occurred during the study. An observed trend maywell represent a drift in analytical performance instead of a truly biological finding. We developed a model that allows for retrospective correction of analytical changes with time. This model is based on theconcept of adjustment of an individual's longitudinal blood biochemistry data by comparing the long-term results of the laboratory with those of other laboratories in an external quality-control survey program. Factors responsible for the analytical bias of our laboratory were identified by multiple regression analysis. The resulting procedure forassessing analytical bias and variability was applied to study in twomutually exclusive cohorts of employees of the Shell petrochemical complex in Rotterdam (a) the true nature of the changes (analytical or biological) in gamma-glutamyltransferase (GGT) and (b) the effect of age on GGT. The first cohort consisted of employees who attended a periodic health assessment in 1984 and in 1989; the second, employees who attended periodic health assessments in 1985 and in 1988. Thus we studied 3- and 5-year changes of GGT corrected for analytical bias. Whereasstandard cross-sectional results apparently showed an increase of GGTup to age 50 years, the longitudinal findings corrected for analytical changes, as indicated above, do not support these cross-sectional results.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 07:46:35