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Titolo:
NEW ASPECTS OF DOPAMINERGIC INTERPLEXIFORM CELL ORGANIZATION IN THE GOLDFISH RETINA
Autore:
VANHAESENDONCK E; MARC RE; MISSOTTEN L;
Indirizzi:
CATHOLIC UNIV LEUVEN,HOSP ST RAFAEL,EYE RES LAB,KAPUCIJNENVOER 33 B-3000 LOUVAIN BELGIUM CATHOLIC UNIV LEUVEN,EYE RES LAB B-3000 LOUVAIN BELGIUM UNIV TEXAS,GRAD SCH BIOMED SCI,CTR SENSORY SCI HOUSTON TX 77030
Titolo Testata:
Journal of comparative neurology
fascicolo: 4, volume: 333, anno: 1993,
pagine: 503 - 518
SICI:
0021-9967(1993)333:4<503:NAODIC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDOLEAMINE-ACCUMULATING CELLS; ADAPTIVE RETINOMOTOR MOVEMENTS; JUNCTION PARTICLE DENSITY; ISOLATED TELEOST RETINAS; HORIZONTAL CELLS; CARP RETINA; TYROSINE-HYDROXYLASE; AMACRINE CELLS; GAP-JUNCTIONS; DENDRITIC MORPHOLOGY;
Keywords:
HORIZONTAL CELLS; DOPAMINE; TYROSINE HYDROXYLASE; GAP JUNCTION; INTERMEDIATE FILAMENT; IMMUNOCYTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
73
Recensione:
Indirizzi per estratti:
Citazione:
E. Vanhaesendonck et al., "NEW ASPECTS OF DOPAMINERGIC INTERPLEXIFORM CELL ORGANIZATION IN THE GOLDFISH RETINA", Journal of comparative neurology, 333(4), 1993, pp. 503-518

Abstract

Dopaminergic interplexiform cells (DA-IPCs) in the goldfish retina have been reexamined by light and electron microscopic immunocytochemistry with antisera against dopamine (DA) or tyrosine hydroxylase (TH). Successful immunostaining with a specific anti-DA antiserum offers further direct support for DA-IPCs. Anti-DA immunocytochemistry in combination with [H-3]-DA autoradiography shows 92% colocalization of the twomarkers, indicating that [H-3]-DA autoradiography is a reliable technique for identification of DA-IPCs. Incubations with anti-TH antiserumshow that immunoreactive DA-IPCs have a homogeneous distribution, with an average frequency of 71 +/- 8 cells/mm2 in retinas of 14-15 cm long goldfish. Their arrangement is distinctly nonrandom. Electron microscopy of TH-immunoreactive cell processes confirms that horizontal cell axons synapse onto DA-IPCs and adds the following junctional arrangements to the circuit diagram of the DA-IPC: 1) adjacent serial synapses between DA-IPCs, external horizontal cells, and putative glycinergicinterplexiform cells, 2) junctional appositions between DA-IPCs and photoreceptor cells, 3) junctional appositions between neighbouring DA-IPCs, and 4) the ''gap junctional complex,'' typically consisting of aDA-IPC process juxtaposed with a gap junction between horizontal cellaxons. The gap junction is flanked by clusters of small, round vesicles and groups of electron-dense structures resembling intermediate filaments. These morphological results support the functional involvementof DA-IPCs in adaptive retinomotor movements and in horizontal cell gap junction modulation and/or dynamics. They also suggest particular interaction between the dopaminergic and the glycinergic IPC system in the outer plexiform layer of goldfish retina.

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Documento generato il 03/07/20 alle ore 00:23:42