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Titolo:
EXPRESSION OF CYTOKINES AND GROWTH-FACTORS IN HUMAN GLOMERULONEPHRITIDES
Autore:
WALDHERR R; NORONHA IL; NIEMIR Z; KRUGER C; STEIN H; STUMM G;
Indirizzi:
UNIV HEIDELBERG,DEPT PATHOL,NEUENHEIMER FELD 220 D-69120 HEIDELBERG GERMANY
Titolo Testata:
Pediatric nephrology
fascicolo: 4, volume: 7, anno: 1993,
pagine: 471 - 478
SICI:
0931-041X(1993)7:4<471:EOCAGI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Keywords:
CYTOKINES; GROWTH FACTORS; ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODY-POSITIVE GLOMERULONEPHRITIS; MESANGIAL IGA GLOMERULONEPHRITIS; IMMUNOCYTOCHEMISTRY; IN-SITU HYBRIDIZATION; POLYMERASE CHAIN REACTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
R. Waldherr et al., "EXPRESSION OF CYTOKINES AND GROWTH-FACTORS IN HUMAN GLOMERULONEPHRITIDES", Pediatric nephrology, 7(4), 1993, pp. 471-478

Abstract

Numerous experimental studies point to the potential role of cytokines and growth factors in the pathogenesis of renal disease. However, from the various autocrine and paracrine mediators identified in vitro and in animal models, so far only a few have been demonstrated in selected human glomerulopathies. We examined two types of glomerulonephritis (GN): extracapillary GN with anti-neutrophil cytoplasmic autoantibodies (ANCA), an example of an acute form of GN, and mesangial IgA GN, usually a chronic form of GN, with immunocytochemistry, in situ hybridization and the polymerase chain reaction. Normal renal tissue from tumour nephrectomies served as a control. In ANCA-positive GN with activerenal lesions (crescents, glomerular and vascular necrosis), infiltrating mononuclear cells in glomeruli and in the interstitium expressed interleukin (IL)-1beta, tumour necrosis factor (TNF)-alpha, IL-2, interferon (IFN)-gamma, platelet-derived growth factor (PDGF) and transforming growth factor (TGF)-beta. Cytokine expression was also observed in activated resident cells, including endothelial cells, capsular epithelial cells, smooth muscle cells of vessel walls, fibroblasts and some tubular epithelial cells. In addition, we noted an increase in the cytokine and growth factor receptors TNF-R, IL-IR type II, IL-2R, IFN-gammaR and PDGFbeta-R. In contrast, in mesangial IgA-GN, IL-1beta, TNF-alpha, IFN-gamma and IL-2 were usually absent in glomeruli. Mesangial expansion in this disorder was accompanied by an increased expression of PDGF, PDGFbeta-R, TGF-beta and IL-6 in mesangial areas. In both conditions a good correlation was observed between cytokine expression atthe mRNA (in situ hybridization) and protein level (immunocytochemistry). These results demonstrate that different cytokine and growth factor patterns are expressed in the various forms of GN, and suggest thatthe local production of these peptides plays an important role in thepathogenesis and progression of human glomerulonephritides.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:08:11