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Titolo:
COEXPRESSION OF TYPE-I AND TYPE-II IL-1 RECEPTORS IN THE MURINE-T HELPER 2 CELL-LINE D10N
Autore:
BRIGELIUSFLOHE R; MCCARTHY JEG; RESCH K; SZAMEL M; MARTIN M;
Indirizzi:
HANNOVER MED SCH,INST MOLEK PHARMAKOL,KONSTANTY GUTSCHOW STR 8 D-30623 HANNOVER GERMANY GBF BRAUNSCHWEIG GERMANY
Titolo Testata:
FEBS letters
fascicolo: 1-3, volume: 326, anno: 1993,
pagine: 204 - 208
SICI:
0014-5793(1993)326:1-3<204:COTATI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL TRANSDUCTION PATHWAYS; INTERLEUKIN-1 RECEPTORS; LYMPHOCYTES-T; B-CELLS; EXPRESSION; ANTAGONIST;
Keywords:
INTERLEUKIN-1 RECEPTOR; INTERLEUKIN-1; INTERLEUKIN-1 RECEPTOR ANTAGONIST; MOUSE-T HELPER CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
R. Brigeliusflohe et al., "COEXPRESSION OF TYPE-I AND TYPE-II IL-1 RECEPTORS IN THE MURINE-T HELPER 2 CELL-LINE D10N", FEBS letters, 326(1-3), 1993, pp. 204-208

Abstract

IL-1 receptor heterogeneity in murine lymphocytes was investigated bycross-linking to [I-125]IL-1alpha and competition with IL-1 receptor antagonist, and the molecular identity of the IL-1 receptors was identified with PCR using primers specific for type I and type II IL-1 receptors. The thymoma cell line EI4 6.1 exhibits exclusively the 80 kDa receptors which proved to be the type I receptor according to PCR analysis. In the pre-B cell fine 70Z/3, predominantly a 60 kDa type II receptor but also a trace of type I receptor can be identified by PCR. TheTh2 cell line D10N expresses both types of IL-1 receptors in equivalent amounts according to cross-linking experiments and PCR. The proliferative response of D10N cells to IL-1 is inhibited by IL-1 ra which according to cross-linking affects the binding to the type I receptor only. It is concluded that coexpression of both types of IL-1 receptors might be a characteristic of murine Th2 cells and that their growth-dependence on IL-1 is mediated by the type I receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 00:24:31