Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DOWN-REGULATION OF PHOSPHO-TYROSINE PHOSPHATASES IN A MACROPHAGE TUMOR
Autore:
SRIDHAR TS; SWARUP G; KHAR A;
Indirizzi:
CTR CELLULAR & MOLEC BIOL,UPPAL RD HYDERABAD 500007 INDIA CTR CELLULAR & MOLEC BIOL,UPPAL RD HYDERABAD 500007 INDIA
Titolo Testata:
FEBS letters
fascicolo: 1-3, volume: 326, anno: 1993,
pagine: 75 - 79
SICI:
0014-5793(1993)326:1-3<75:DOPPIA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROUS-SARCOMA VIRUS; PROTEIN-KINASE; GENE-PRODUCT; RAT SPLEEN; CELL-CYCLE; EXPRESSION; PHOSPHORYLATION; TRANSFORMATION; PURIFICATION; ONCOGENES;
Keywords:
PHOSPHO-TYROSINE PHOSPHATASE; DOWN-REGULATION; MALIGNANCY; RAT MACROPHAGE CELL LINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
T.S. Sridhar et al., "DOWN-REGULATION OF PHOSPHO-TYROSINE PHOSPHATASES IN A MACROPHAGE TUMOR", FEBS letters, 326(1-3), 1993, pp. 75-79

Abstract

We provide evidence for the downregulation of phospho-tyrosine phosphatases (PTPases) in malignancy. AK-5, a rat macrophage tumor, shows the downregulation of the transcripts of two non-receptor-type PTPases, PTP-1 and PTP-S. Though downregulated fourfold, the genomic organization of PTP-S is unaltered. There is no gross alteration of the PTPase activity in AK-5 as compared to macrophages. Immunoblot analysis reveals no significant change in the total phospho-tyrosine levels in AK-5, but there is a qualitative difference in the pattern between AK-5 and macrophages. Our results lend credence to the conjecture that PTPases also might be involved in malignancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:27:46