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Titolo:
CELLULAR PHARMACOKINETICS OF DOXORUBICIN IN PATIENTS WITH CHRONIC LYMPHOCYTIC-LEUKEMIA - COMPARISON OF BOLUS ADMINISTRATION AND CONTINUOUS-INFUSION
Autore:
MULLER C; CHATELUT E; GUALANO V; DEFORNI M; HUGUET F; ATTAL M; CANAL P; LAURENT G;
Indirizzi:
HOP PURPAN,SERV HEMATOL,PL DR BAYLAC F-31059 TOULOUSE FRANCE CTR CLAUDIUS REGAUD,PHARMACOL CLIN & EXPTL MEDICAMENTS ANTICANC GRP F-31052 TOULOUSE FRANCE
Titolo Testata:
Cancer chemotherapy and pharmacology
fascicolo: 5, volume: 32, anno: 1993,
pagine: 379 - 384
SICI:
0344-5704(1993)32:5<379:CPODIP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMBINATION CHEMOTHERAPY; MALIGNANT-LYMPHOMAS; EXPRESSION; RESISTANCE; PLASMA; AGENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
C. Muller et al., "CELLULAR PHARMACOKINETICS OF DOXORUBICIN IN PATIENTS WITH CHRONIC LYMPHOCYTIC-LEUKEMIA - COMPARISON OF BOLUS ADMINISTRATION AND CONTINUOUS-INFUSION", Cancer chemotherapy and pharmacology, 32(5), 1993, pp. 379-384

Abstract

The purpose of this study was to determine whether administration of doxorubicin (DOX) as a continuous infusion or a bolus injection resulted in similar leukemic cell drug concentration in patients with refractory chronic lymphocytic leukemia (CLL). This study was carried out onfive patients with refractory CLL, with DOX administered either as a bolus injection (35 mg/m2; CHOP protocol) or as a constant-rate infusion for a period of 96 h (9 mg/m2 per day; VAD protocol). The two typesof drug administration were used alternatively with the same patient. Plasma and cellular DOX concentration were determined using high-performance liquid chromatography. Peak plasma DOX levels were higher after the bolus injection than after continuous administration (1509 +/- 80 ng/ml vs 11.6 +/- 1.8 ng/ml, respectively), whereas the plasma area under the curve (AUC) levels were similar. Maximum DOX cellular concentrations were 8629 +/- 2902 ng/10(9) cells (bolus injection) and 2745 /- 673 ng/10(9) cells (96 h infusion). The cellular AUC after the bolus injection was 2.85 times greater than that observed after continuous administration. This difference was due to a higher cellular peak level followed by a relatively prolonged retention of the drug, with a loss of only 25% in the first 24 h following. These findings demonstrated that in CLL the cellular DOX exposure can be notably modified by the method of drug administration, with higher drug intracellular concentrations being achieved after bolus administration than with the infusion schedule.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:09:15