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Titolo:
ROLE IN GROWTH-REGULATION OF CYTOKINES AND CYTOKINE RECEPTORS IN ACUTE LYMPHOBLASTIC-LEUKEMIA EXPRESSING MYELOID MARKERS
Autore:
KOMADA Y; ZHOU YW; ZHANG SL; AZUMA E; SAKURAI M;
Indirizzi:
MIE UNIV,SCH MED,DEPT PAEDIAT,2-174 EDOBASHI TSU MIE 514 JAPAN
Titolo Testata:
British Journal of Haematology
fascicolo: 3, volume: 84, anno: 1993,
pagine: 408 - 415
SICI:
0007-1048(1993)84:3<408:RIGOCA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYELOBLASTIC-LEUKEMIA; GM-CSF; CELLS; INTERLEUKIN-1; DIFFERENTIATION; AUTOCRINE; CHILDHOOD; CHILDREN; CULTURE; SERUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
Y. Komada et al., "ROLE IN GROWTH-REGULATION OF CYTOKINES AND CYTOKINE RECEPTORS IN ACUTE LYMPHOBLASTIC-LEUKEMIA EXPRESSING MYELOID MARKERS", British Journal of Haematology, 84(3), 1993, pp. 408-415

Abstract

The biological roles of cytokines and cytokine receptors were examined in acute lymphoblastic leukaemia cells expressing myeloid antigens (My+ ALL). Interleukin-3 (IL-3), granulocyte-colony stimulating factor (G-CSF), granulocyte-macrophage-CSF (GM-CSF), and low molecular-weightB-cell growth factor (LW-BCGF) could induce DNA synthesis in certain cases of My+ ALL. Whereas in My- ALL the stimulatory effects were shown only with LW-BCGF. Acute myelogenous leukaemia (AML) cells were activated with multiple cytokines including interleukin-I (IL-1), IL-3, G-CSF and GM-CSF. Specific receptors for IL-1 and IL-3 were strongly expressed on both My+ and My- ALL cells. These receptors, however, were weakly detectable on AML cells. Additionally we studied the production of tumour necrosis factor-alpha and IL-1 by leukaemic blasts and foundthat distinct amounts of both cytokines were released from My+ ALL cells and AML cells, but not from My- ALL cells. The profiles of cytokines and cytokine receptors expressed by My+ ALL showed both similaries and differences to those in My- ALL or AML. The proliferation of My+ ALL cells was dependent. on multiple cytokines that would regulate growth and maturation in a lineage-restricted fashion. These data suggested that My+ ALL cells might originate from uncommitted haematopoietic precursor cells coexpressing features of both lymphoid and myeloid lineages.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:44:41