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Titolo:
TUMORS IN HEPATOBILIARY TRACT AND PANCREATIC-ISLET TISSUES OF TRANSGENIC MICE HARBORING GASTRIN SIMIAN VIRUS-40 LARGE TUMOR-ANTIGEN FUSION GENE
Autore:
MONTAG AG; OKA T; BAEK KH; CHOI CS; JAY G; AGARWAL K;
Indirizzi:
UNIV CHICAGO,DEPT PATHOL CHICAGO IL 60637 UNIV CHICAGO,DEPT PATHOL CHICAGO IL 60637 AMER RED CROSS,JEROME H HOLLAND LAB,VIROL LAB ROCKVILLE MD 20855 UNIV CHICAGO,DEPT BIOCHEM & MOLEC BIOL CHICAGO IL 60637
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 14, volume: 90, anno: 1993,
pagine: 6696 - 6700
SICI:
0027-8424(1993)90:14<6696:TIHTAP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; PROMOTER; EXPRESSION; CONTAINS; SEQUENCE;
Keywords:
DEVELOPMENTAL REGULATION; GENE EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
A.G. Montag et al., "TUMORS IN HEPATOBILIARY TRACT AND PANCREATIC-ISLET TISSUES OF TRANSGENIC MICE HARBORING GASTRIN SIMIAN VIRUS-40 LARGE TUMOR-ANTIGEN FUSION GENE", Proceedings of the National Academy of Sciences of the United Statesof America, 90(14), 1993, pp. 6696-6700

Abstract

Gastrin is expressed in the gastric antrum and in fetal pancreatic islets but not in adult islets. We have now identified the hepatobiliarytract as another, previously unknown, potential site of gastrin gene expression. Two human gastrin simian virus 40 large tumor antigen (SV40 T antigen) fusion genes containing 1.5 kb of 5' flanking sequence and 10.5 kb that included 5.5 kb upstream, 1.5 kb downstream, and the entire transcribed region were used to generate transgenic mice. Analysis of several transgenic lines, derived from both fusion genes, revealed development of transmissible hepatobiliary tract tumors and pancreatic islet cell tumors. Analysis of each of the tumor cells demonstratesexpression of SV40 T antigen but no expression of gastrin. Of the twofusion genes, only the 10.5-kb sequence induces hyperplasia of gastrin-producing cells in the antrum. Analysis of these cells demonstrates expression of SV40 T antigen and gastrin, suggesting that the 10.5-kb sequence is sufficient for gastrin cell hyperplasia in the antrum. These data raise the possibility that gastrin is transiently expressed inthe hepatobiliary tract.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:33:18