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Titolo:
TREATMENT OF CHRONIC-RELAPSING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS WITH THE SYNTHETIC IMMUNOMODULATOR LINOMIDE (QUINOLINE-3-CARBOXAMIDE)
Autore:
KARUSSIS DM; LEHMANN D; SLAVIN S; VOURKAKARUSSIS U; MIZRACHIKOLL R; OVADIA H; KALLAND T; ABRAMSKY O;
Indirizzi:
HEBREW UNIV JERUSALEM,HADASSAH HOSP,DEPT BONE MARROW TRANSPLANTAT,EINKEREM IL-91120 JERUSALEM ISRAEL HEBREW UNIV JERUSALEM,HADASSAH HOSP,DEPT BONE MARROW TRANSPLANTAT,EINKEREM IL-91120 JERUSALEM ISRAEL HEBREW UNIV JERUSALEM,HADASSAH HOSP,DEPT NEUROL IL-91120 JERUSALEM ISRAEL HEBREW UNIV JERUSALEM,HADASSAH HOSP,CANC IMMUNOBIOL RES LAB IL-91120 JERUSALEM ISRAEL
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 14, volume: 90, anno: 1993,
pagine: 6400 - 6404
SICI:
0027-8424(1993)90:14<6400:TOCEAE>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MYELIN BASIC-PROTEIN; KILLER CELL-ACTIVITY; MULTIPLE-SCLEROSIS; MICE; MOUSE; DISEASE; LS-2616; CYCLOSPORIN; PREVENTION;
Keywords:
MULTIPLE SCLEROSIS; NATURAL KILLER CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
D.M. Karussis et al., "TREATMENT OF CHRONIC-RELAPSING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS WITH THE SYNTHETIC IMMUNOMODULATOR LINOMIDE (QUINOLINE-3-CARBOXAMIDE)", Proceedings of the National Academy of Sciences of the United Statesof America, 90(14), 1993, pp. 6400-6404

Abstract

Linomide is a synthetic immunomodulator that enhances natural killer cell activity and significantly activates several lymphocytic cell subpopulations in both experimental animals and humans. In this study we examined the effect of linomide (80 mg per kg per day in drinking water) on mice with chronic-relapsing experimental autoimmune encephalomyelitis (CR-EAE), a T-cell-mediated organ-specific autoimmune disease that resembles human multiple sclerosis. None of the mice (n = 17) that were treated with linomide from day 7 after disease induction developed any dinical or histopathological signs of CR-EAE, as compared to 19 of 20 untreated controls that were severely paralyzed and had extensive demyelinating lesions in the central nervous system. Linomide-treated animals were also resistant to an induced attack by a booster injection with a murine spinal cord homogenate. When administered to mice exhibiting severe clinical signs of paralysis, linomide inhibited both spontaneous and induced relapses. Linomide treatment protected mice from passively induced CR-EAE as well, when given from the day of injection with myelin-basic-protein-specific lymphocytes. Lymphocytes obtained from linomide-treated mice had a reduced in vitro proliferative response to the myelin basic protein and to the tuberculin purified protein derivative, whereas the mitogenic response to concanavalin A was notaffected. Natural killer cell and lymphokine-activated killer cell activities were enhanced. These results suggest that linomide regulates autoimmunity in the absence of systemic immunosuppression. Since linomide is very well tolerated in experimental animals and humans, it might be used in the treatment of multiple sclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 15:53:56