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Titolo:
MAST-CELLS CONTRIBUTE TO THE CHANGES IN HEART-RATE, BUT NOT HYPOTENSION OR DEATH, ASSOCIATED WITH ACTIVE ANAPHYLAXIS IN MICE
Autore:
MARTIN TR; ANDO A; TAKEISHI T; KATONA IM; DRAZEN JM; GALLI SJ;
Indirizzi:
CHILDRENS HOSP MED CTR,DIV PULM,300 LONGWOOD AVE BOSTON MA 02115 CHILDRENS HOSP MED CTR,INA SUE PERLMUTTER LAB,DEPT PEDIAT BOSTON MA 02115 HARVARD UNIV,SCH MED BOSTON MA 02115 BETH ISRAEL HOSP,DEPT MED BOSTON MA 02215 BETH ISRAEL HOSP,DEPT PATHOL BOSTON MA 02215 BETH ISRAEL HOSP,DIV EXPTL PATHOL BOSTON MA 02215 BRIGHAM & WOMENS HOSP,DEPT MED BOSTON MA 02115 UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT BETHESDA MD 20814 UNIFORMED SERV UNIV HLTH SCI,DEPT MED BETHESDA MD 20814
Titolo Testata:
The Journal of immunology
fascicolo: 1, volume: 151, anno: 1993,
pagine: 367 - 376
SICI:
0022-1767(1993)151:1<367:MCTTCI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOPULMONARY ALTERATIONS; SYSTEMIC-ANAPHYLAXIS; IMMUNE-RESPONSE; DEFICIENT MICE; SERUM IGE; MOUSE; W/WV; ACTIVATION; REACTIVITY; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
T.R. Martin et al., "MAST-CELLS CONTRIBUTE TO THE CHANGES IN HEART-RATE, BUT NOT HYPOTENSION OR DEATH, ASSOCIATED WITH ACTIVE ANAPHYLAXIS IN MICE", The Journal of immunology, 151(1), 1993, pp. 367-376

Abstract

The mast cell is widely thought to contribute importantly to the cardiopulmonary changes associated with anaphylaxis, but much of the evidence for this is indirect. We, therefore, performed a detailed assessment of heart rate and pulmonary function during active anaphylaxis in genetically mast cell-deficient W/W(v) or S1/S1d mice, the congenic normal (+/+) mice, and W/W(v) mice repaired of their mast cell deficiencyby transplantation of bone marrow from the congenic +/+ mice (+/+BM-->W/W(v) mice). For all five groups of mice, Ag challenge resulted in the death of more than two-thirds of the sensitized animals, whereas none of the nonsensitized control mice died as a result of Ag infusion. Sensitized normal (WBB6F1-+/+ or WCB6F1-+/+) mice and +/+BM-->W/W(v) mice developed increases in heart rate that were significantly greater than those of nonsensitized +/+ mice or those of sensitized mast cell-deficient mice, indicating that mast cells contribute to the tachycardia observed in this form of active anaphylaxis. By contrast, even though some of the pulmonary changes associated with active anaphylaxis were more severe in +/+ than in mast cell-deficient mice, it was not clear to what extent this difference was mast cell dependent. W/W(v) miceundergoing active anaphylaxis developed decreases in systemic arterial blood pressure that occurred more rapidly and were more severe than those observed in the congenic +/+ mice, indicating that the hypotension associated with this model of anaphylaxis also can occur by mast cell-independent mechanisms. We conclude that in this model of anaphylaxis mast cells: 1) are required for the development of the tachycardia response; 2) may contribute to, but are not essential for, production of decreases in lung function; and 3) are not necessary for the development of hypotension or death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 02:55:26