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Titolo:
EFFECT OF DIETS HIGH IN SODIUM AND POTASSIUM ON THE MAGNITUDE OF THEOPHYLLINE-INDUCED HYPERCALCIURIA IN THE RAT
Autore:
WHITING SJ;
Indirizzi:
UNIV SASKATCHEWAN,COLL PHARM,DIV NUTR & DIETET SASKATOON S7N 0W0 SASKATCHEWAN CANADA
Titolo Testata:
International journal for vitamin and nutrition research
fascicolo: 2, volume: 63, anno: 1993,
pagine: 150 - 155
SICI:
0300-9831(1993)63:2<150:EODHIS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY CALCIUM EXCRETION; MAGNESIUM; CAFFEINE; PHOSPHORUS; WOMEN; SALTS;
Keywords:
SODIUM CHLORIDE; SODIUM BICARBONATE; THEOPHYLLINE; DIURESIS; POTASSIUM CHLORIDE; POTASSIUM; BICARBONATE; URINE CALCIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
S.J. Whiting, "EFFECT OF DIETS HIGH IN SODIUM AND POTASSIUM ON THE MAGNITUDE OF THEOPHYLLINE-INDUCED HYPERCALCIURIA IN THE RAT", International journal for vitamin and nutrition research, 63(2), 1993, pp. 150-155

Abstract

The effects of dietary sodium and potassium, given as salts of chloride or bicarbonate, on theophylline-induced hypercalciuria in the rat were investigated. In experiment 1, rats fed diets containing 0.3 mmol/g diet NaCl, KCl, NaHCO3, or KHCO3 exhibited a calciuria of NaCl > KCl> controls = NaHCO3 = KHCO3. This study indicated that cation effectswere dependent on the accompanying anion, however the dose of added salt was inadequate to produce a consistent, significant salt effect. Asecond experiment was run in which animals were given salts at 0.4 mmol/g diet; the salt-induced pattern of calciuria was similar. After one week of salt pretreatment, rats were given diets containing theophylline (7.72 mumol/g diet), which induced calciuria all groups regardless of salt pretreatment. Urinary volume and urinary phosphate changes were parallel to each other and not to the changes in urinary calcium induced by salt or theophylline. Changes in urinary excretion of prostaglandin E2 were directly proportional to changes in urinary calcium. In the rat, pretreatment with sodium bicarbonate or sodium chloride reduces the extent of theophylline-induced diuresis, but does not reduce theophylline-induced hypercalciuria. Further, potassium chloride increases and potassium bicarbonate does not reduce urinary calcium excretion. Theophylline-induced calciuria is correlated with prostaglandin E2excretion rates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:13:49