Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE CAROTID-BODY IN THE MOTOR-NEURON RESPONSE TO PROTRIPTYLINE
Autore:
OKU Y; BRUCE EN; RICHMONDS CR; HUDGEL DW;
Indirizzi:
METROHLTH MED CTR,PULM & CRIT MED,2500 METROHLTH DR CLEVELAND OH 44109 METROHLTH MED CTR,PULM & CRIT MED,2500 METROHLTH DR CLEVELAND OH 44109 CASE WESTERN RESERVE UNIV CLEVELAND OH 44106 UNIV KENTUCKY LEXINGTON KY 40506
Titolo Testata:
Respiration physiology
fascicolo: 1, volume: 93, anno: 1993,
pagine: 41 - 49
SICI:
0034-5687(1993)93:1<41:TCITMR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE ACTIVITY; SLEEP-APNEA; HYPOGLOSSAL;
Keywords:
CAROTID BODIES, INSPIRATORY ACTIVITY; CONTROL OF BREATHING, INSPIRATORY MUSCLES, PROTRIPTYLINE; MAMMALS, RAT; MUSCLES, INSPIRATORY; NERVES, INSPIRATORY MOTOR; PHARMACOLOGICAL AGENTS, PROTRIPTYLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
Y. Oku et al., "THE CAROTID-BODY IN THE MOTOR-NEURON RESPONSE TO PROTRIPTYLINE", Respiration physiology, 93(1), 1993, pp. 41-49

Abstract

Protriptyline (PRT) has been shown to preferentially stimulate upper airway inspiratory motorneurons relative to phrenic activity in hyperoxic hypercapnia in the decerebrate cat via a carotid body-independent mechanism. Since previous studies indicated that carotid body stimulation results in preferential activation of upper airway respiratory muscles during both hypercapnia and hypoxemia, we hypothesized that if PRT preferentially stimulated upper airway motorneurons, the mechanism of action might involve the carotid body. We investigated the effect ofPRT on carotid body function by comparing the electrical activity of the hypoglossal (HYP) with that of the phrenic (PHR) nerve in carotid sinus nerve intact (CSNI) and CSN-sectioned (CSNX) anesthetized rats, before and after PRT (0.5 mg/kg i.v.), during 100% O2, 15% O2 (N2 balance), and 4% CO2 (O2 balance) administration. The moving time average (MTA) peak inspiratory electroneurogram activities of both the HYP andPHR nerves increased an equivalent amount after PRT injection during hyperoxia, in both CSNI and CSNX rats. During hypoxia, the HYP activity increased significantly more than the PHR activity only in CSNI ratsafter PRT injection. During hyperoxic hypercapnia, HYP MTAs increaseda similar amount in the CSNI and CSNX rats. We conclude that the HYP and PHR respiratory motorneuron pool responses to PRT depend on the blood gas status at the time of drug administration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:20:13