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Titolo:
RELATIONSHIP BETWEEN SKELETAL-MUSCLE LIPOPROTEIN-LIPASE ACTIVITY AND 24-HOUR MACRONUTRIENT OXIDATION
Autore:
FERRARO RT; ECKEL RH; LARSON DE; FONTVIEILLE AM; RISING R; JENSEN DR; RAVUSSIN E;
Indirizzi:
NIDDKD,CLIN DIABET & NUTR SECT PHOENIX AZ 85016 NIDDKD,CLIN DIABET & NUTR SECT PHOENIX AZ 85016 UNIV COLORADO,HLTH SCI CTR,DEPT MED DENVER CO 80262
Titolo Testata:
The Journal of clinical investigation
fascicolo: 1, volume: 92, anno: 1993,
pagine: 441 - 445
SICI:
0021-9738(1993)92:1<441:RBSLAA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIMA-INDIANS; INSULIN RESISTANCE; WEIGHT-GAIN; OBESITY; GLUCOSE; ETIOLOGY; EXERCISE; RATS;
Keywords:
LIPOPROTEIN LIPASE; 24-H RESPIRATORY QUOTIENT; EUGLYCEMIC, HYPERINSULINEMIC CLAMP; SKELETAL MUSCLE; HUMAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
R.T. Ferraro et al., "RELATIONSHIP BETWEEN SKELETAL-MUSCLE LIPOPROTEIN-LIPASE ACTIVITY AND 24-HOUR MACRONUTRIENT OXIDATION", The Journal of clinical investigation, 92(1), 1993, pp. 441-445

Abstract

A low ratio of whole-body 24-h fat/carbohydrate (CHO) oxidation has been shown to be a predictor of subsequent body weight gain. We tested the hypothesis that the variability of this ratio may be related to differences in skeletal muscle metabolism. Since lipoprotein lipase (LPL) plays a pivotal role in partitioning lipoprotein-borne triglyceridesto adipose (storage) and skeletal muscle (mostly (oxidation), we postulated that a low ratio of fat/CHO oxidation was associated with a lowskeletal muscle LPL (SMLPL) activity. As an index of substrate oxidation, 24-h RQ was measured under sedentary and eucaloric conditions in 16 healthy nondiabetic Pima males. During a 6-h euglycemic, hyperinsulinemic clamp, muscle biopsies were obtained at baseline, 3, and 6 h. Heparin-elutable SMLPL activity was 2.92 +/- 0.56 nmol free fatty acids/g . min (mean +/- SD) at baseline, was unchanged (2.91 +/- 0.51) at the third hour, and increased significantly (P < 0.05) to 3.13 +/- 0.57at the sixth hour of the clamp. The mean (of baseline and 3-h) SMLPL activity correlated inversely with 24-h RQ (r = 0.57, P < 0.03) but not with body size, body composition, or insulin-mediated glucose uptake. Since SMLPL activity is related to the ratio of whole body fat/CHO oxidation rate, a decreased muscle LPL activity may, therefore, predispose to obesity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 06:55:08