Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANALYSIS OF A GENETIC HITCHHIKING MODEL, AND ITS APPLICATION TO DNA POLYMORPHISM DATA FROM DROSOPHILA-MELANOGASTER
Autore:
WIEHE THE; STEPHAN W;
Indirizzi:
UNIV MARYLAND,DEPT ZOOL COLL PK MD 20742 UNIV MARYLAND,DEPT ZOOL COLL PK MD 20742 UNIV MARYLAND,PROGRAM APPL MATH COLL PK MD 20742
Titolo Testata:
Molecular biology and evolution
fascicolo: 4, volume: 10, anno: 1993,
pagine: 842 - 854
SICI:
0737-4038(1993)10:4<842:AOAGHM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACHAETE-SCUTE REGION; NATURAL-POPULATIONS; X-CHROMOSOME;
Keywords:
DNA SEQUENCE VARIATION; GENETIC HITCHHIKING; ADVANTAGEOUS MUTATIONS; MOLECULAR POPULATION GENETICS; DROSOPHILA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
T.H.E. Wiehe e W. Stephan, "ANALYSIS OF A GENETIC HITCHHIKING MODEL, AND ITS APPLICATION TO DNA POLYMORPHISM DATA FROM DROSOPHILA-MELANOGASTER", Molecular biology and evolution, 10(4), 1993, pp. 842-854

Abstract

Begun and Aquadro have demonstrated that levels of nucleotide variation correlate with recombination rate among 20 gene regions from acrossthe genome of Drosophila melanogaster. It has been suggested that this correlation results from genetic hitchhiking associated with the fixation of strongly selected mutants. The hitchhiking process can be described as a series of two-step events. The first step consists of a strongly selected substitution wiping out linked variation in a population; this is followed by a recovery period in which polymorphism can build up via neutral mutations and random genetic drift. Genetic hitchhiking has previously been modeled as a steady-state process driven by recurring selected substitutions. We show here that the characteristic parameter of this steady-state model is alphanu, the product of selection intensity (alpha = 2Ns) and the frequency of beneficial mutations nu (where N is population size and s is the selective advantage of thefavored allele). We also demonstrate that the steady-state model describes the hitchhiking process adequately, unless the recombination rate is very low. To estimate alphanu, we use the data of DNA sequence variation from 17 D. melanogaster loci from regions of intermediate to high recombination rates. We find that alphanu is likely to be > 1.3 x 10(-8). Additional data are needed to estimate this parameter more precisely. The estimation of alphanu is important, as this parameter determines the shape of the frequency distribution of strongly selected substitutions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:15:17