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Titolo:
EFFECTS OF PROPRANOLOL AND DILTIAZEM ON THE RATE OF HIGH-ENERGY PHOSPHATE-METABOLISM IN REPERFUSED RAT HEARTS - P-31-NMR SATURATION-TRANSFER STUDY
Autore:
OKAYAMA Y; KOBAYASHI A; FUJISE Y; YAMAZAKI N;
Indirizzi:
HAMAMATSU UNIV,SCH MED,DEPT INTERNAL MED 3,3600 HANDA CHO HAMAMATSU SHIZUOKA 431-31 JAPAN HAMAMATSU UNIV,SCH MED,DEPT INTERNAL MED 3,3600 HANDA CHO HAMAMATSU SHIZUOKA 431-31 JAPAN
Titolo Testata:
Japanese Circulation Journal
fascicolo: 6, volume: 57, anno: 1993,
pagine: 521 - 532
SICI:
0047-1828(1993)57:6<521:EOPADO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CREATINE-KINASE REACTION; CROSS-BRIDGE KINETICS; MAGNETIZATION TRANSFER; STUNNED MYOCARDIUM; RABBIT HEART; MUSCLE; ATP; DYSFUNCTION; VELOCITY; TENSION;
Keywords:
SATURATION TRANSFER; REPERFUSED HEART; PROPRANOLOL; DILTIAZEM; P-31-NMR; HIGH-ENERGY PHOSPHATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
Y. Okayama et al., "EFFECTS OF PROPRANOLOL AND DILTIAZEM ON THE RATE OF HIGH-ENERGY PHOSPHATE-METABOLISM IN REPERFUSED RAT HEARTS - P-31-NMR SATURATION-TRANSFER STUDY", Japanese Circulation Journal, 57(6), 1993, pp. 521-532

Abstract

The relationships between pressure rate product (PRP) and flux (PCr-->ATP) or flux (Pi-->ATP) were studied in isolated perfused rat hearts by the saturation transfer method using P-31-NMR. The effects of propranolol and diltiazem on phosphate metabolism were also studied. After a 40 min preischemic period, the hearts were subjected to a 15 min period of ischemia, followed by 60 min of reperfusion. Propranolol (0.4-1.2 muM) or diltiazem (3.0-6.0 muM) was infused for 30 min before ischemia and reinfused after reperfusion for 60 min. The flux (PCr-->ATP)/PRP ratio at reperfusion did not differ from that at preischemia. This value was also not affected by propranolol or diltiazem treatment. However, the flux (Pi-->ATP)/PRP ratio at reperfusion was significantly less than that at preischemia. Moreover, this value was significantly improved by propranolol or diltiazem treatment. This study demonstratesthat 1) flux (PCr-->ATP) has a good correlation with cardiac performance, 2) stunned myocardium needs less ATP turnover for survival of itsdepressed contractile activity, and 3) flux (Pi-->ATP) can limit recovery of postischemic performance. Protective effects of propranolol and diltiazem are exerted on the flux (Pi-->ATP), i.e. ATP derived from glycolytic flux, in the reperfused heart.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 08:50:16