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Titolo:
EFFECT OF DIABETES AND AGING ON HUMAN SYMPATHETIC AUTONOMIC GANGLIA
Autore:
SCHMIDT RE; PLURAD SB; PARVIN CA; ROTH KA;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PATHOL,DIV NEUROPATHOL,660 S EUCLID AVE ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT LAB MED ST LOUIS MO 63110
Titolo Testata:
The American journal of pathology
fascicolo: 1, volume: 143, anno: 1993,
pagine: 143 - 153
SICI:
0002-9440(1993)143:1<143:EODAAO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR; GASTROINTESTINAL MOTILITY; NEUROAXONAL DYSTROPHY; NEUROPATHY; MELLITUS; RATS; AGE; GLYCOSYLATION; DISORDERS; SEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
R.E. Schmidt et al., "EFFECT OF DIABETES AND AGING ON HUMAN SYMPATHETIC AUTONOMIC GANGLIA", The American journal of pathology, 143(1), 1993, pp. 143-153

Abstract

Although autonomic dysfunction frequently complicates the clinical course of patients with diabetes, relatively little is known of its underlying neuropathology. Using experimental animal models as a guide, the prevertebral superior mesenteric (SMG) and paravertebral superior cervical (SCG) sympathetic ganglia have been examined in a series of adult autopsied diabetic and non-diabetic patients of various ages using histochemical, ultrastructural, morphometric, and immunohistochemical methods. Quantitative studies demonstrated that markedly swollen argyrophilic terminal axons (neuroaxonal dystrophy) containing large numbers of disorganized neurofilaments developed in the SMG but not SCG as afunction of diabetes, increasing age, and gender (males were more severely affected than females). As in experimental animals, diabetic (types I and II) patients developed histologically identical lesions prematurely and in greater numbers than age-matched nondiabetic patients. Morphometric studies showed a small but statistically significant decrease in neuronal density in the SMG but not SCG of diabetic patients. The dimensions of individual sympathetic neurons were not significantly different in aging or diabetes. The pathological lesions identified in the SMG may contribute to the autonomic dysfunction so commonly observed in diabetic patients.

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Documento generato il 07/07/20 alle ore 21:18:09