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Titolo:
BETA-APP GENE-EXPRESSION IS INCREASED IN THE RAT-BRAIN AFTER MOTOR-NEURON AXOTOMY
Autore:
SOLA C; GARCIALADONA FJ; SARASA M; MENGOD G; PROBST A; PALACIOS G; PALACIOS JM;
Indirizzi:
CSIC,CID,DEPT NEUROCHEM,C JORDI GIRONA 18-26 E-08034 BARCELONA SPAIN CSIC,CID,DEPT NEUROCHEM,C JORDI GIRONA 18-26 E-08034 BARCELONA SPAIN CSIC,CID,DEPT PHARMACOL & TOXICOL E-08034 BARCELONA SPAIN SANDOZ PHARMA LTD,PRECLIN RES DEPT CH-4002 BASEL SWITZERLAND UNIV BASEL,INST PATHOL,DEPT NEUROPATHOL CH-4003 BASEL SWITZERLAND LABS ALMIRALL SA BARCELONA SPAIN UNIV ZARAGOZA,FAC VET,DEPT ANAT EMBRYOL & GENET ZARAGOZA SPAIN UNIV AUTONOMA BARCELONA,FAC MED,DEPT CELLULAR BIOL & PHYSIOL,SUBUNIT HISTOL BARCELONA SPAIN
Titolo Testata:
European journal of neuroscience
fascicolo: 7, volume: 5, anno: 1993,
pagine: 795 - 808
SICI:
0953-816X(1993)5:7<795:BGIIIT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; FIBRILLARY ACIDIC PROTEIN; ALZHEIMERS-DISEASE BRAIN; FACIAL-NERVE AXOTOMY; MESSENGER-RNA; INSITU HYBRIDIZATION; DIFFERENTIAL EXPRESSION; CYTOSKELETAL PROTEINS; CEREBRAL-CORTEX; NUCLEUS BASALIS;
Keywords:
BETA/A4; BETA-AMYLOID PRECURSOR PROTEIN; NEURONAL REGENERATION; ALZHEIMERS DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
C. Sola et al., "BETA-APP GENE-EXPRESSION IS INCREASED IN THE RAT-BRAIN AFTER MOTOR-NEURON AXOTOMY", European journal of neuroscience, 5(7), 1993, pp. 795-808

Abstract

The response of the betaAPP gene to neuronal injury was studied in the facial and hypoglossal nerve nuclei of the rat after corresponding nerve axotomy. Increased levels of betaAPP 695, 714, 751 and 770 mRNAs were observed after either facial or hypoglossal nerve axotomy in the parent ipsilateral motor neurons. The increase was gradual, with maximal values 7 days after axotomy. BetaAPP mRNA expression returned to normal values 60 days after the lesion. Increased betaAPP immunostainingwas also detected in ipsilateral chromatolytic motor neurons. No change in betaAPP immunoreactivity was observed in oligodendrocytes, another cell type expressing betaAPP under normal conditions. A rapid increase in the expression of the GFAP gene was observed in reactive astrocytes surrounding chromatolytic neurons in the ipsilateral facial or hypoglossal nuclei. Thus, in contrast with other models of neuronal injury, where only the Kunitz protease inhibitor-containing betaAPP mRNA isoforms are increased, all betaAPP mRNAs are increased in the axotomy model. Furthermore, although betaAPP expression has been shown to be increased in reactive astrocytes following neuronal injury, in the present study the increase was essentially found in the motor neurons reacting to axotomy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 21:49:37