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Titolo:
A CASE-CONTROL STUDY OF ELEMENT LEVELS AND CANCER OF THE UPPER AERODIGESTIVE TRACT
Autore:
ROGERS MAM; THOMAS DB; DAVIS S; VAUGHAN TL; NEVISSI AE;
Indirizzi:
SUNY HLTH SCI CTR,DEPT PREVENT MED,750 E ADAMS ST SYRACUSE NY 13210 SUNY HLTH SCI CTR,DEPT MED SYRACUSE NY 13210 FRED HUTCHINSON CANC RES CTR,PROGRAM EPIDEMIOL SEATTLE WA 98104 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 98195 UNIV WASHINGTON,DEPT ENVIRONM HLTH SEATTLE WA 98195
Titolo Testata:
Cancer epidemiology, biomarkers & prevention
fascicolo: 4, volume: 2, anno: 1993,
pagine: 305 - 312
SICI:
1055-9965(1993)2:4<305:ACSOEL>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND INTERVENTION; BODY IRON STORES; EPIDEMIOLOGIC EVIDENCE; SERUM FERRITIN; DIETARY IRON; RISK; ZINC; CALCIUM; COBALT; NAIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
M.A.M. Rogers et al., "A CASE-CONTROL STUDY OF ELEMENT LEVELS AND CANCER OF THE UPPER AERODIGESTIVE TRACT", Cancer epidemiology, biomarkers & prevention, 2(4), 1993, pp. 305-312

Abstract

A population-based case-control study was conducted in western Washington state to investigate possible dietary risk factors for laryngeal,esophageal, and oral cancers. Using results from a food frequency questionnaire, past dietary intakes of iron, zinc, and calcium were estimated for 661 cases and 466 controls. Clippings were also taken from the nails of both halluces to determine concentrations of iron, zinc, calcium, chromium, and cobalt in 507 of the cases and 434 of the controls. After adjustment for smoking, alcohol, and dietary beta-carotene and vitamin C intake, individuals who reported dietary intakes of iron and zinc in the upper quartile were less likely to develop cancers of the larynx and esophagus than were individuals with intakes in the lowest quartile [odds ratios (OR), 0.5 for iron and 0.1 for zinc]. However, there were no significant differences in zinc concentrations in nailtissue between subjects with these types of cancer and controls. Esophageal cancer cases had higher nail concentrations of iron and calciumthan did controls (OR, 2.9 for high versus low quartiles of iron; OR,2.6 for high versus low quartiles of calcium). Individuals who developed esophageal or oral cancer were more likely to have elevated cobaltconcentrations in their nail tissue than were individuals without cancer (OR, 9.0 and 1.9 respectively, for high versus low quartiles). Theresults of this study suggest that there may be differences in mineral intake or metabolism between individuals who develop some carcinomasof the upper aerodigestive tract and those who do not.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 19:08:36