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Titolo:
THE PROTOONCOGENE C-SEA ENCODES A TRANSMEMBRANE PROTEIN-TYROSINE KINASE RELATED TO THE MET HEPATOCYTE GROWTH-FACTOR SCATTER FACTOR-RECEPTOR
Autore:
HUFF JL; JELINEK MA; BORGMAN CA; LANSING TJ; PARSONS JT;
Indirizzi:
UNIV VIRGINIA,DEPT MICROBIOL,BOX 441 CHARLOTTESVILLE VA 22908 UNIV VIRGINIA,DEPT MICROBIOL,BOX 441 CHARLOTTESVILLE VA 22908 UNIV VIRGINIA,CTR CANC CHARLOTTESVILLE VA 22908
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 13, volume: 90, anno: 1993,
pagine: 6140 - 6144
SICI:
0027-8424(1993)90:13<6140:TPCEAT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
AVIAN RETROVIRUS; RIBONUCLEIC-ACID; EGF-RECEPTOR; ONCOGENE; S13; IDENTIFICATION; SEQUENCE; TRANSFORMATION; PRODUCT; FAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Huff et al., "THE PROTOONCOGENE C-SEA ENCODES A TRANSMEMBRANE PROTEIN-TYROSINE KINASE RELATED TO THE MET HEPATOCYTE GROWTH-FACTOR SCATTER FACTOR-RECEPTOR", Proceedings of the National Academy of Sciences of the United Statesof America, 90(13), 1993, pp. 6140-6144

Abstract

c-sea is the cellular homologue of the avian erythroblastosis virus S13-encoded oncogene v-sea. We have isolated and determined the nucleotide sequence of overlapping chicken cDNAs that encode the putative c-sea protooncogene product. The predicted reading frame encoded a 1404-aa polypeptide that had the structure of a receptor-like protein-tyrosine kinase and exhibited the highest degree of sequence similarity withthe Met/hepatocyte growth factor/scatter factor receptor. Analysis ofsteady-state RNA expression revealed that c-sea mRNA levels were elevated almost-equal-to 5-fold in chicken embryo cells transformed by activated variants of the src nonreceptor protein-tyrosine kinase gene but not in cells transformed by the nuclear oncogenes v-myc or v-rel A survey of c-sea expression in a variety of chicken tissues indicated that the highest levels of mRNA were located in peripheral white blood cell populations and in the intestine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:55:53