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Titolo:
COLOCALIZATION OF X-LINKED AGAMMAGLOBULINEMIA AND X-LINKED IMMUNODEFICIENCY GENES
Autore:
THOMAS JD; SIDERAS P; SMITH CIE; VORECHOVSKY I; CHAPMAN V; PAUL WE;
Indirizzi:
NIAID,IMMUNOL LAB BETHESDA MD 20892 NIAID,IMMUNOL LAB BETHESDA MD 20892 KAROLINSKA INST,NOVUM,CTR BIOTECHNOL S-14157 HUDDINGE SWEDEN UMEA UNIV,APPL CELL & MOLEC BIOL UNIT S-90187 UMEA SWEDEN NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,DEPT MOLEC BIOL BUFFALO NY 14263
Titolo Testata:
Science
fascicolo: 5119, volume: 261, anno: 1993,
pagine: 355 - 358
SICI:
0036-8075(1993)261:5119<355:COXAAX>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
B-CELLS; IMMUNE-DEFICIENCY; LYMPHOCYTES-B; SRC GENE; 5' EXONS; C-SRC; MICE; MUTATION; PROTEIN; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
J.D. Thomas et al., "COLOCALIZATION OF X-LINKED AGAMMAGLOBULINEMIA AND X-LINKED IMMUNODEFICIENCY GENES", Science, 261(5119), 1993, pp. 355-358

Abstract

Mice that bear the X-linked immunodeficiency (xid) mutation have a B lymphocyte-specific defect resulting in an inability to make antibody responses to polysaccharide antigens. A backcross of 1114 progeny revealed the colocalization of xid with Bruton's agammaglobulinemia tyrosine kinase (btk) gene, which is implicated in the human immune deficiency, X-linked agammaglobulinemia. Mice that carry xid have a missense mutation that alters a highly conserved arginine near the amino-terminus of the btk protein, Btk. Because this region of Btk lies outside anyobvious kinase domain, the xid mutation may define another aspect of tyrosine kinase function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 20:49:31